Interstitial pneumonitis following autologous bone marrow transplantation

John R. Wingard, Mark B. Sostrin, Huibert M. Vriesendorp, E. David Meldits, George W. Santos, Donald J. Fuller, Hayden G. Braine, Andrew M. Yeacer, William H. Burns, Rein Saral

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P≤0.001 for both comparisons).

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalTransplantation
Volume46
Issue number1
DOIs
StatePublished - Jul 1988

ASJC Scopus subject areas

  • Transplantation

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