Intestinal maturation in the rat: The effect of glucocorticoids on sodium, potassium, water and glucose absorption

R. Meneely, Fayez K Ghishan

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Abstract

The effect of glucocorticoids on the intestinal transport of water, electrolytes, and glucose in the infancy period is not known. Therefore, we studied the effect of parenteral glucocorticoids on intestinal transport of water, electrolytes and glucose in suckling rats with an in vivo single pass perfusion technique. Glucocorticoids enhanced significantly net sodium transport only in the colon segments compared to controls. Net sodium transport in the small intestinal segments was similar in glucocorticoid and control groups. Similar to adult animals, glucocorticoids enhanced glucose transport in the ileum, but not in jejunum segments. Net potassiunm absorption was decreased five-fold in jejunum segments and reversed to net secretion in the ileum and colon segments by glucocorticoids. These results are the first to extend the known effects of glucocorticoids into the infancy period.

Original languageEnglish (US)
Pages (from-to)776-778
Number of pages3
JournalPediatric Research
Volume16
Issue number9
Publication statusPublished - 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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