Intestinal maturation: In vivo magnesium transport

R. Meneely, L. Leeper, Fayez K Ghishan

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We investigated with an in vivo single pass perfusion technique net transport of magnesium in the jejunum, ileum and colon segments of suckling, weanling and adolescent rats. The concentration of magnesium in the isotonic chloride solution perfused through the intestinal segments was either below (0 and 0.5 mmoles/liter) or above (1, 2.5 and 5 mmoles/liter) serum ionized magnesium. The relationship between net transport rates (μmoles/h per g dry weight) and luminal magnesium concentration was linear in all three intestinal segments of the suckling rats. In the weanling and adolescent rats, the relationship between net transport and luminal magnesium concentration was linear in the small intestinal segments; however, a change to a saturable, curvilinear relationship was noted in the colon segments. Rates of transport were significantly greater in all segments of suckling rats compared to corresponding segments of the adolescent rats, when luminal magnesium concentration was 2.5 and 5 mmoles/liter. Net transport rates in the colonic segments at all ages were either equal to or greater than rates in the small intestinal segment at the same age period. The change in the relationship between transport rates and luminal magnesium in the colonic segments suggested that the mode of magnesium transport changed at the time of weaning from mainly a passive mechanism in the suckling period to mainly a carrier mediated mechanism in the adolescent rats. This is the first demonstration of developmental characteristics of magnesium transport in animals. The change in the rate and characteristics of net magnesium transport in the rat during maturation reflects a greater permeability of the intestinal membranes in the suckling compared to adolescent rats. The mechanism(s) responsible for the changes in the intestinal permeability could be the result of hormonal changes which occur during the weanling period.

Original languageEnglish (US)
Pages (from-to)295-298
Number of pages4
JournalPediatric Research
Volume16
Issue number4 I
StatePublished - 1982
Externally publishedYes

Fingerprint

Magnesium
Permeability
Colon
Isotonic Solutions
Jejunum
Weaning
Ileum
Chlorides
Perfusion
Weights and Measures
Membranes
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Intestinal maturation : In vivo magnesium transport. / Meneely, R.; Leeper, L.; Ghishan, Fayez K.

In: Pediatric Research, Vol. 16, No. 4 I, 1982, p. 295-298.

Research output: Contribution to journalArticle

Meneely, R, Leeper, L & Ghishan, FK 1982, 'Intestinal maturation: In vivo magnesium transport', Pediatric Research, vol. 16, no. 4 I, pp. 295-298.
Meneely, R. ; Leeper, L. ; Ghishan, Fayez K. / Intestinal maturation : In vivo magnesium transport. In: Pediatric Research. 1982 ; Vol. 16, No. 4 I. pp. 295-298.
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