Intestinal Transplantation

Khalid M. Khan, Tun Jie, Chirag S. Desai, Rainer W.G. Gruessner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Continuity with its environment makes the intestine a unique abdominal organ. Apart from its nutritional role, it contains a large amount of lymphoid tissue and intimately interacts with microbial flora. The lymphoid element within the gut has a necessary, complex immunological role, so it was always deemed an intuitive barrier to intestinal transplantation. Nevertheless, Richard Lillehei at the University of Minnesota saw the potential for transplanting the small intestine in patients with intestinal failure and performed the first such transplant in the 1960s. Early refinements in surgical technique were followed by advances in immunosuppression and a better appreciation of post-transplant care; today, an intestinal transplant (ITx) is a well-established option in clinical practice.

Original languageEnglish (US)
Title of host publicationAbdominal Organ Transplantation
Subtitle of host publicationState of the Art
PublisherJohn Wiley and Sons
Pages150-162
Number of pages13
ISBN (Print)9781444334326
DOIs
StatePublished - Dec 23 2012

Keywords

  • ITx
  • Intestinal transplantation
  • Isolated intestinal transplant
  • Liver-intestine transplant
  • Multivisceral transplant

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Khan, K. M., Jie, T., Desai, C. S., & Gruessner, R. W. G. (2012). Intestinal Transplantation. In Abdominal Organ Transplantation: State of the Art (pp. 150-162). John Wiley and Sons. https://doi.org/10.1002/9781118483664.ch8