Intracellular amyloid-β in Alzheimer's disease

Frank M. LaFerla, Kim N. Green, Salvatore - Oddo

Research output: Contribution to journalArticle

1255 Scopus citations


The primal role that the amyloid-β (Aβ) peptide has in the development of Alzheimer's disease is now almost universally accepted. It is also well recognized that Aβ exists in multiple assembly states, which have different physiological or pathophysiological effects. Although the classical view is that Aβ is deposited extracellularly, emerging evidence from transgenic mice and human patients indicates that this peptide can also accumulate intraneuronally, which may contribute to disease progression.

Original languageEnglish (US)
Pages (from-to)499-509
Number of pages11
JournalNature Reviews Neuroscience
Issue number7
Publication statusPublished - Jul 2007
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)
  • Cell Biology

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