Abstract
Frontal EEG alpha asymmetry provides a promising index of depression risk, yet very little is known about the neural sources of alpha asymmetry. To identify these sources, this study examined alpha asymmetry using a distributed inverse solution: exact low resolution brain electromagnetic tomography (eLORETA). Findings implicated a generator in lateral midfrontal regions that contributed to both surface asymmetry and depression risk. Participants with any lifetime history of depressive episodes were characterized by less left than right activity in the precentral gyrus and midfrontal gyrus. Anhedonia accounted for a significant portion of the relationship between alpha asymmetry and lifetime major depressive disorder. Results are suggestive of convergence between motivational and capability models of asymmetry and replicate results from experimental studies in a large resting-state data set. The capability model of frontal alpha asymmetry is contextualized in terms of motor preparedness following emotional mobilization.
| Original language | English (US) |
|---|---|
| Article number | e13019 |
| Journal | Psychophysiology |
| Volume | 55 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2018 |
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Keywords
- anhedonia
- depression
- EEG alpha asymmetry
- eLORETA
- emotion
- source estimation
ASJC Scopus subject areas
- Physiology
- Neuropsychology and Physiological Psychology
- Experimental and Cognitive Psychology
- Physiology (medical)
Cite this
Intracranial source activity (eLORETA) related to scalp-level asymmetry scores and depression status. / Smith, Ezra E.; Cavanagh, James F.; Allen, John JB.
In: Psychophysiology, Vol. 55, No. 1, e13019, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intracranial source activity (eLORETA) related to scalp-level asymmetry scores and depression status
AU - Smith, Ezra E.
AU - Cavanagh, James F.
AU - Allen, John JB
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Frontal EEG alpha asymmetry provides a promising index of depression risk, yet very little is known about the neural sources of alpha asymmetry. To identify these sources, this study examined alpha asymmetry using a distributed inverse solution: exact low resolution brain electromagnetic tomography (eLORETA). Findings implicated a generator in lateral midfrontal regions that contributed to both surface asymmetry and depression risk. Participants with any lifetime history of depressive episodes were characterized by less left than right activity in the precentral gyrus and midfrontal gyrus. Anhedonia accounted for a significant portion of the relationship between alpha asymmetry and lifetime major depressive disorder. Results are suggestive of convergence between motivational and capability models of asymmetry and replicate results from experimental studies in a large resting-state data set. The capability model of frontal alpha asymmetry is contextualized in terms of motor preparedness following emotional mobilization.
AB - Frontal EEG alpha asymmetry provides a promising index of depression risk, yet very little is known about the neural sources of alpha asymmetry. To identify these sources, this study examined alpha asymmetry using a distributed inverse solution: exact low resolution brain electromagnetic tomography (eLORETA). Findings implicated a generator in lateral midfrontal regions that contributed to both surface asymmetry and depression risk. Participants with any lifetime history of depressive episodes were characterized by less left than right activity in the precentral gyrus and midfrontal gyrus. Anhedonia accounted for a significant portion of the relationship between alpha asymmetry and lifetime major depressive disorder. Results are suggestive of convergence between motivational and capability models of asymmetry and replicate results from experimental studies in a large resting-state data set. The capability model of frontal alpha asymmetry is contextualized in terms of motor preparedness following emotional mobilization.
KW - anhedonia
KW - depression
KW - EEG alpha asymmetry
KW - eLORETA
KW - emotion
KW - source estimation
UR - http://www.scopus.com/inward/record.url?scp=85041018422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041018422&partnerID=8YFLogxK
U2 - 10.1111/psyp.13019
DO - 10.1111/psyp.13019
M3 - Article
C2 - 29023805
AN - SCOPUS:85041018422
VL - 55
JO - Psychophysiology
JF - Psychophysiology
SN - 0048-5772
IS - 1
M1 - e13019
ER -