Intralesional Recombinant Alpha-2 Interferon for the Treatment of Patients With Condyloma Acuminatum or Verruca Plantaris

J. Corwin Vance, Bruce J. Bart, Ronald C. Hansen, Richard C. Reichman, Christopher McEwen, Kenneth D Hatch, Brian Berman, Daniel J. Tanner

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

• We conducted a multicenter double-blind study comparing human recombinant intralesional alpha-2 interferon (IFN) and placebo in 237 patients with the clinical diagnosis of condyloma acuminatum or verruca plantaris. A single wart on each patient was injected with 0.1 mL containing 106 IU of IFN, 105 IU of IFN, or placebo three times weekly for three weeks, and the response to treatment was followed up for 12 weeks. Among 91 of the 114 patients with condyloma acuminatum who completed the study, complete clearing of the treated wart occurred in 16 (53%) of 30 patients receiving 106 IU of IFN compared with six (19%) of 32 receiving 105 IU of IFN and four (14%) of 29 receiving placebo. In the group of 100 patients with plantar warts, there was no apparent benefit associated with interferon administration. Seven patients (3%) had treatment discontinued due to adverse reactions. Intralesional alpha-2 IFN is of benefit in the treatment of a single condyloma; its role in the treatment of multiple lesions remains to be clarified. Its role in the treatment of verruca plantaris, where no response was seen, also remains to be clarified.

Original languageEnglish (US)
Pages (from-to)272-277
Number of pages6
JournalArchives of Dermatology
Volume122
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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