Intranuclear trafficking and gene targeting by members of the steroid/nuclear receptor superfamily

Gordon L. Hager, Catharine L. Smith, Gilberto Fragoso, Ron Wolford, Dawn Walker, Julia Barsony, Han Htun

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Upon binding to regulatory elements in mammalian chromosomes, steroid receptors induce specific transitions in the nucleoprotein structure of the template. These transitions reflect, in part, the reorganization of chromatin structure to permit interaction of secondary factors with target sequences in promoter regulatory regions. Steroid receptors represent a class of transcriptional activators that are able to interact with repressed nucleoprotein templates and recruit necessary activities for chromatin remodeling. The ligand-induced movement of nuclear receptors from inactive states, either in the cytoplasm or in the nucleus, to productive interactions with chromatin is complex and likely reflects the interaction with multiple protein complexes and subcellular structures. Regulation of gene expression by nuclear receptors is thus mediated through the subcellular distribution of inactive receptors, the redistribution of activated receptor complexes to appropriate nuclear domains, the reorganization of chromatin structures for interaction with soluble components of the nucleoplasm, and direct protein- protein contacts between receptors and the basal transcription apparatus.

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume65
Issue number1-6
DOIs
StatePublished - Apr 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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