Intraoperative coincidence probe for tumor detection with 111In-labelled monoclonal antibodies

K. J. Matherson, H. B. Barber, Harrison H Barrett, N. E. Hartsough, J. M. Woolfenden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

We are developing a compact, light-weight coincidence-detection probe comprised of a 1 cm3 CsI(Tl) scintillator, Si photodiode and hybrid preamplifier. We characterized performance of a prototype probe in bench tests. The characterization consisted of: point source response vs. distance, energy spectra, and coincidence time constant measurements. Coincidences from 111In are present in a well-isolated sum peak at 416 keV in the energy spectrum. The energy resolution of the sum peak is 11% Full Width Half Maximum (FWHM). The point source response decreases as the fourth power of the distance from the source. We also compared detector performance with that of a single-gamma-detecting probe in simulations using a numerical torso phantom into which biodistribution data for an 111In-labeled monoclonal antibody had been entered. The Hotelling trace value (HTV) was used as the figure of merit. The coincidence-detection probe has an order of magnitude better Hotelling trace value than the single-gamma-detecting probe in the simulations. The coincidence-detection probe shows promise for practical intraoperative tumor localization with 111In-labeled radiopharmaceuticals.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium & Medical Imaging Conference
PublisherPubl by IEEE
Pages1312-1316
Number of pages5
Editionpt 2
ISBN (Print)0780314875
StatePublished - 1994
EventProceedings of the 1993 IEEE Nuclear Science Symposium & Medical Imaging Conference - San Francisco, CA, USA
Duration: Oct 30 1993Nov 6 1993

Other

OtherProceedings of the 1993 IEEE Nuclear Science Symposium & Medical Imaging Conference
CitySan Francisco, CA, USA
Period10/30/9311/6/93

Fingerprint

Monoclonal antibodies
Tumors
Photodiodes
Phosphors
Detectors

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Matherson, K. J., Barber, H. B., Barrett, H. H., Hartsough, N. E., & Woolfenden, J. M. (1994). Intraoperative coincidence probe for tumor detection with 111In-labelled monoclonal antibodies. In IEEE Nuclear Science Symposium & Medical Imaging Conference (pt 2 ed., pp. 1312-1316). Publ by IEEE.

Intraoperative coincidence probe for tumor detection with 111In-labelled monoclonal antibodies. / Matherson, K. J.; Barber, H. B.; Barrett, Harrison H; Hartsough, N. E.; Woolfenden, J. M.

IEEE Nuclear Science Symposium & Medical Imaging Conference. pt 2. ed. Publ by IEEE, 1994. p. 1312-1316.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Matherson, KJ, Barber, HB, Barrett, HH, Hartsough, NE & Woolfenden, JM 1994, Intraoperative coincidence probe for tumor detection with 111In-labelled monoclonal antibodies. in IEEE Nuclear Science Symposium & Medical Imaging Conference. pt 2 edn, Publ by IEEE, pp. 1312-1316, Proceedings of the 1993 IEEE Nuclear Science Symposium & Medical Imaging Conference, San Francisco, CA, USA, 10/30/93.
Matherson KJ, Barber HB, Barrett HH, Hartsough NE, Woolfenden JM. Intraoperative coincidence probe for tumor detection with 111In-labelled monoclonal antibodies. In IEEE Nuclear Science Symposium & Medical Imaging Conference. pt 2 ed. Publ by IEEE. 1994. p. 1312-1316
Matherson, K. J. ; Barber, H. B. ; Barrett, Harrison H ; Hartsough, N. E. ; Woolfenden, J. M. / Intraoperative coincidence probe for tumor detection with 111In-labelled monoclonal antibodies. IEEE Nuclear Science Symposium & Medical Imaging Conference. pt 2. ed. Publ by IEEE, 1994. pp. 1312-1316
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