Intraoperative coincidence probe for tumor detection with 111In-labelled monoclonal antibodies

K. J. Matherson, H. B. Barber, H. H. Barrett, N. E. Hartsough, J. M. Woolfenden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

We are developing a compact, light-weight coincidence-detection probe comprised of a 1 cm3 CsI(Tl) scintillator, Si photodiode and hybrid preamplifier. We characterized performance of a prototype probe in bench tests. The characterization consisted of: point source response vs. distance, energy spectra, and coincidence time constant measurements. Coincidences from 111In are present in a well-isolated sum peak at 416 keV in the energy spectrum. The energy resolution of the sum peak is 11% Full Width Half Maximum (FWHM). The point source response decreases as the fourth power of the distance from the source. We also compared detector performance with that of a single-gamma-detecting probe in simulations using a numerical torso phantom into which biodistribution data for an 111In-labeled monoclonal antibody had been entered. The Hotelling trace value (HTV) was used as the figure of merit. The coincidence-detection probe has an order of magnitude better Hotelling trace value than the single-gamma-detecting probe in the simulations. The coincidence-detection probe shows promise for practical intraoperative tumor localization with 111In-labeled radiopharmaceuticals.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium & Medical Imaging Conference
PublisherPubl by IEEE
Pages1312-1316
Number of pages5
Editionpt 2
ISBN (Print)0780314875
StatePublished - Jan 1 1994
EventProceedings of the 1993 IEEE Nuclear Science Symposium & Medical Imaging Conference - San Francisco, CA, USA
Duration: Oct 30 1993Nov 6 1993

Publication series

NameIEEE Nuclear Science Symposium & Medical Imaging Conference
Numberpt 2

Other

OtherProceedings of the 1993 IEEE Nuclear Science Symposium & Medical Imaging Conference
CitySan Francisco, CA, USA
Period10/30/9311/6/93

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering

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  • Cite this

    Matherson, K. J., Barber, H. B., Barrett, H. H., Hartsough, N. E., & Woolfenden, J. M. (1994). Intraoperative coincidence probe for tumor detection with 111In-labelled monoclonal antibodies. In IEEE Nuclear Science Symposium & Medical Imaging Conference (pt 2 ed., pp. 1312-1316). (IEEE Nuclear Science Symposium & Medical Imaging Conference; No. pt 2). Publ by IEEE.