Intraoperative fluorescent imaging of intracranial tumors: A review

Milad Behbahaninia, Nikolay L. Martirosyan, Joseph Georges, Joshua A. Udovich, M. Yashar S Kalani, Burt G.F. Feuerstein, Peter Nakaji, Robert F. Spetzler, Mark C. Preul

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A review of fluorescent imaging for intracranial neoplasms is presented. Complete resection of brain cancer is seldom possible because of the goal to preserve brain tissue and the inability to visualize individual infiltrative tumor cells. Verification of histology and identification of tumor invasion in macroscopically normal-appearing brain tissue determine prognosis after resection of malignant gliomas. Therefore, imaging modalities aim to facilitate intraoperative decision-making. Intraoperative fluorescent imaging techniques have the potential to enable precise histopathologic diagnosis and to detect tumor remnants in the operative field. Macroscopic fluorescence imaging is effective for gross tumor detection. Microscopic imaging techniques enhance the sensitivity of the macroscopic observations and provide real-time histological information. Further development of clinical grade fluorescent agents specifically targeting tumor cells could improve the diagnostic and prognostic yield of intraoperative imaging.

Original languageEnglish (US)
Pages (from-to)517-528
Number of pages12
JournalClinical Neurology and Neurosurgery
Volume115
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Neoplasms
Brain Neoplasms
Optical Imaging
Brain
Fluorescent Dyes
Glioma
Decision Making
Histology

Keywords

  • 5-Aminolevulinic acid
  • Brain tumors
  • Confocal endomicroscopy
  • Confocal microscopy
  • Fluorescence
  • Gliomas
  • Intraoperative imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Behbahaninia, M., Martirosyan, N. L., Georges, J., Udovich, J. A., Kalani, M. Y. S., Feuerstein, B. G. F., ... Preul, M. C. (2013). Intraoperative fluorescent imaging of intracranial tumors: A review. Clinical Neurology and Neurosurgery, 115(5), 517-528. https://doi.org/10.1016/j.clineuro.2013.02.019

Intraoperative fluorescent imaging of intracranial tumors : A review. / Behbahaninia, Milad; Martirosyan, Nikolay L.; Georges, Joseph; Udovich, Joshua A.; Kalani, M. Yashar S; Feuerstein, Burt G.F.; Nakaji, Peter; Spetzler, Robert F.; Preul, Mark C.

In: Clinical Neurology and Neurosurgery, Vol. 115, No. 5, 05.2013, p. 517-528.

Research output: Contribution to journalArticle

Behbahaninia, M, Martirosyan, NL, Georges, J, Udovich, JA, Kalani, MYS, Feuerstein, BGF, Nakaji, P, Spetzler, RF & Preul, MC 2013, 'Intraoperative fluorescent imaging of intracranial tumors: A review', Clinical Neurology and Neurosurgery, vol. 115, no. 5, pp. 517-528. https://doi.org/10.1016/j.clineuro.2013.02.019
Behbahaninia, Milad ; Martirosyan, Nikolay L. ; Georges, Joseph ; Udovich, Joshua A. ; Kalani, M. Yashar S ; Feuerstein, Burt G.F. ; Nakaji, Peter ; Spetzler, Robert F. ; Preul, Mark C. / Intraoperative fluorescent imaging of intracranial tumors : A review. In: Clinical Neurology and Neurosurgery. 2013 ; Vol. 115, No. 5. pp. 517-528.
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