Abstract
Near-infrared contrast agents are becoming more frequently studied due to their advantageous characteristics, most notably the ability to work in the tissue transparency window of the electromagnetic spectrum. This produces a need for imaging technology that can be specific for both the NIR dye and the discipline. Indocyanine green is currently the primary NIR dye used in neurosurgery. Here we report on using the previously described augmented microscope for image guidance in a rat glioma resection. Luc-C6 cells were implanted in a rat in the left-frontal lobe and grown for 22 days. Surgical resection was performed by a neurosurgeon using augmented microscopy guidance with ICG contrast. Videos and images were acquired to evaluate image quality and resection margins. ICG accumulated in the tumor tissue due to enhanced permeation and retention from the compromised blood-brain-barrier. The augmented microscope was capable of guiding the rat glioma resection and highlighted tumor tissue regions via ICG signal.
| Original language | English (US) |
|---|---|
| Title of host publication | Molecular-Guided Surgery: Molecules, Devices, and Applications II |
| Publisher | SPIE |
| Volume | 9696 |
| ISBN (Electronic) | 9781628419306 |
| DOIs | |
| State | Published - 2016 |
| Event | Molecular-Guided Surgery: Molecules, Devices, and Applications II - San Francisco, United States Duration: Feb 13 2016 → Feb 14 2016 |
Other
| Other | Molecular-Guided Surgery: Molecules, Devices, and Applications II |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 2/13/16 → 2/14/16 |
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ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Intraoperative imaging using intravascular contrast agent. / Watson, Jeffrey R.; Martirosyan, Nikolay; Garland, Summer; Lemole, Gerald M; Romanowski, Marek.
Molecular-Guided Surgery: Molecules, Devices, and Applications II. Vol. 9696 SPIE, 2016. 96960L.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Intraoperative imaging using intravascular contrast agent
AU - Watson, Jeffrey R.
AU - Martirosyan, Nikolay
AU - Garland, Summer
AU - Lemole, Gerald M
AU - Romanowski, Marek
PY - 2016
Y1 - 2016
N2 - Near-infrared contrast agents are becoming more frequently studied due to their advantageous characteristics, most notably the ability to work in the tissue transparency window of the electromagnetic spectrum. This produces a need for imaging technology that can be specific for both the NIR dye and the discipline. Indocyanine green is currently the primary NIR dye used in neurosurgery. Here we report on using the previously described augmented microscope for image guidance in a rat glioma resection. Luc-C6 cells were implanted in a rat in the left-frontal lobe and grown for 22 days. Surgical resection was performed by a neurosurgeon using augmented microscopy guidance with ICG contrast. Videos and images were acquired to evaluate image quality and resection margins. ICG accumulated in the tumor tissue due to enhanced permeation and retention from the compromised blood-brain-barrier. The augmented microscope was capable of guiding the rat glioma resection and highlighted tumor tissue regions via ICG signal.
AB - Near-infrared contrast agents are becoming more frequently studied due to their advantageous characteristics, most notably the ability to work in the tissue transparency window of the electromagnetic spectrum. This produces a need for imaging technology that can be specific for both the NIR dye and the discipline. Indocyanine green is currently the primary NIR dye used in neurosurgery. Here we report on using the previously described augmented microscope for image guidance in a rat glioma resection. Luc-C6 cells were implanted in a rat in the left-frontal lobe and grown for 22 days. Surgical resection was performed by a neurosurgeon using augmented microscopy guidance with ICG contrast. Videos and images were acquired to evaluate image quality and resection margins. ICG accumulated in the tumor tissue due to enhanced permeation and retention from the compromised blood-brain-barrier. The augmented microscope was capable of guiding the rat glioma resection and highlighted tumor tissue regions via ICG signal.
UR - http://www.scopus.com/inward/record.url?scp=84978634533&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978634533&partnerID=8YFLogxK
U2 - 10.1117/12.2213867
DO - 10.1117/12.2213867
M3 - Conference contribution
VL - 9696
BT - Molecular-Guided Surgery: Molecules, Devices, and Applications II
PB - SPIE
ER -