Intraoperative tumor detection: relative performance of single-element, dual-element, and imaging probes with various collimators

N. E. Hartsough, H. H. Barrett, H. B. Barber, J. M. Woolfenden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Accurate tumor staging depends on finding all tumor sites, and curative surgery requires the removal of all cancerous tissue from those sites. One technique for locating tumors is to inject patients before surgery with a radiotracer that is preferentially taken up by cancerous tissue. Then an intra-operative gamma-sensitive probe is used to locate the tumors. Small (< 1 cm diameter) tumors can be found with probes. These tumors are often undetectable by external imaging and the standard surgical inspection with sight and touch. Simple calculations and model tumor tests show that small tumors should be detected by single-element probes, but often such probes fail to detect them in practice. This discrepancy is often caused by the use of a uniform background to predict probe performance. Real backgrounds are nonuniform and the variations in the background decrease probe performance dramatically. We devised a method to predict probe performance in a realistic background which includes variations in normal organ uptakes. We predict the relative performance of probes, both existing devices and those still in the design stage. Since probe configurations can be compared without actually building devices, optimal detector and collimator configurations can be determined. The procedure uses a Monte-Carlo-calculated point response function, a numerical torso phantom (provided by George Zubal of Yale University) obtained from computed tomography slices of a normal male, and estimated biodistribution data derived from actual biodistributions of a monoclonal antibody. The Hotelling Trace Value, a measure of the tumor-detection performance, is computed from the probe responses at 5000 simulated sites. We present the relative detection performances of single-element, dual-element, imaging, and coincidence probes and determine the optimal configuration for collimation of an imaging probes.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium & Medical Imaging Conference
PublisherPubl by IEEE
Pages1236-1240
Number of pages5
Editionpt 2
ISBN (Print)0780314875
StatePublished - Jan 1 1994
EventProceedings of the 1993 IEEE Nuclear Science Symposium & Medical Imaging Conference - San Francisco, CA, USA
Duration: Oct 30 1993Nov 6 1993

Publication series

NameIEEE Nuclear Science Symposium & Medical Imaging Conference
Numberpt 2

Other

OtherProceedings of the 1993 IEEE Nuclear Science Symposium & Medical Imaging Conference
CitySan Francisco, CA, USA
Period10/30/9311/6/93

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ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering

Cite this

Hartsough, N. E., Barrett, H. H., Barber, H. B., & Woolfenden, J. M. (1994). Intraoperative tumor detection: relative performance of single-element, dual-element, and imaging probes with various collimators. In IEEE Nuclear Science Symposium & Medical Imaging Conference (pt 2 ed., pp. 1236-1240). (IEEE Nuclear Science Symposium & Medical Imaging Conference; No. pt 2). Publ by IEEE.