Intraperitoneal chemotherapy: Phase III trials

David S Alberts, Mary C. Clouser

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

It is well documented that epithelial-type ovarian cancer growth remains within the intraperitoneal (IP) space for the majority of its natural history, making even advanced disease (e.g., stage III) amenable to regional therapy. The concept of IP delivery of chemotherapy goes back more than 40 years to the bioengineer, Robert Dedrick, whose research group at the National Institutes of Health developed animal and mathematical models to describe the disposition of cytotoxic agents administered directly into the IP space [1]. Most notably, his preclinical research led to the belly bath as a way of delivering cell-cycle specific agents by continuous 4 h infusions, leading to phase I/II clinical trials of IP 5-fluorouracil and methotrexate in patients with advanced ovarian cancer at the National Cancer Institute (NCI) [2, 3].

Original languageEnglish (US)
Title of host publicationIntraperitoneal Therapy for Ovarian Cancer
PublisherSpringer Berlin Heidelberg
Pages37-50
Number of pages14
ISBN (Print)9783642121296
DOIs
StatePublished - 2010

Fingerprint

Drug Therapy
Phase II Clinical Trials
Clinical Trials, Phase I
National Cancer Institute (U.S.)
Cytotoxins
National Institutes of Health (U.S.)
Natural History
Baths
Research
Methotrexate
Fluorouracil
Ovarian Neoplasms
Cell Cycle
Theoretical Models
Animal Models
Growth
Therapeutics
Ovarian epithelial cancer

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Alberts, D. S., & Clouser, M. C. (2010). Intraperitoneal chemotherapy: Phase III trials. In Intraperitoneal Therapy for Ovarian Cancer (pp. 37-50). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-12130-2_4

Intraperitoneal chemotherapy : Phase III trials. / Alberts, David S; Clouser, Mary C.

Intraperitoneal Therapy for Ovarian Cancer. Springer Berlin Heidelberg, 2010. p. 37-50.

Research output: Chapter in Book/Report/Conference proceedingChapter

Alberts, DS & Clouser, MC 2010, Intraperitoneal chemotherapy: Phase III trials. in Intraperitoneal Therapy for Ovarian Cancer. Springer Berlin Heidelberg, pp. 37-50. https://doi.org/10.1007/978-3-642-12130-2_4
Alberts DS, Clouser MC. Intraperitoneal chemotherapy: Phase III trials. In Intraperitoneal Therapy for Ovarian Cancer. Springer Berlin Heidelberg. 2010. p. 37-50 https://doi.org/10.1007/978-3-642-12130-2_4
Alberts, David S ; Clouser, Mary C. / Intraperitoneal chemotherapy : Phase III trials. Intraperitoneal Therapy for Ovarian Cancer. Springer Berlin Heidelberg, 2010. pp. 37-50
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