Intraperitoneal chemotherapy: Technical experience at five institutions

Martine J. Piccart, James L. Speyer, Maurie Markman, WW ten Bokkel Huinink, David S Alberts, Jean Jenkins, Franco Muggia

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

With the rapid expansion of research programs examining intraperitoneal chemotherapy for ovarian cancer and other intraabdominal malignancies, there is a need for a reliable and safe access to the peritoneal cavity. The technical experience accumulated with either the Tenckhoff catheter or the Port-A-Cath in 288 patients treated at five institutions showed a low incidence of catheter-related peritonitis (5% and 8%, respectively), skin infection (6.6% and 0%), and bowel perforation following surgical implantation (3.5% and 1.3%). Postoperative leakage of intraabdominal fluid, bleeding, or ileus were uncommon and easily controlled. Drainage failure was the major problem with both systems; occurring in 45% of patients. Although both systems are workable, improved catheters for the administration of intraperitoneal chemotherapy are warranted.

Original languageEnglish (US)
Pages (from-to)90-96
Number of pages7
JournalSeminars in Oncology
Volume12
Issue number3 SUPPL. 4
StatePublished - 1985

Fingerprint

Catheters
Drug Therapy
Vascular Access Devices
Ileus
Peritoneal Cavity
Peritonitis
Ovarian Neoplasms
Drainage
Hemorrhage
Skin
Incidence
Infection
Research
Neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

Piccart, M. J., Speyer, J. L., Markman, M., ten Bokkel Huinink, WW., Alberts, D. S., Jenkins, J., & Muggia, F. (1985). Intraperitoneal chemotherapy: Technical experience at five institutions. Seminars in Oncology, 12(3 SUPPL. 4), 90-96.

Intraperitoneal chemotherapy : Technical experience at five institutions. / Piccart, Martine J.; Speyer, James L.; Markman, Maurie; ten Bokkel Huinink, WW; Alberts, David S; Jenkins, Jean; Muggia, Franco.

In: Seminars in Oncology, Vol. 12, No. 3 SUPPL. 4, 1985, p. 90-96.

Research output: Contribution to journalArticle

Piccart, MJ, Speyer, JL, Markman, M, ten Bokkel Huinink, WW, Alberts, DS, Jenkins, J & Muggia, F 1985, 'Intraperitoneal chemotherapy: Technical experience at five institutions', Seminars in Oncology, vol. 12, no. 3 SUPPL. 4, pp. 90-96.
Piccart MJ, Speyer JL, Markman M, ten Bokkel Huinink WW, Alberts DS, Jenkins J et al. Intraperitoneal chemotherapy: Technical experience at five institutions. Seminars in Oncology. 1985;12(3 SUPPL. 4):90-96.
Piccart, Martine J. ; Speyer, James L. ; Markman, Maurie ; ten Bokkel Huinink, WW ; Alberts, David S ; Jenkins, Jean ; Muggia, Franco. / Intraperitoneal chemotherapy : Technical experience at five institutions. In: Seminars in Oncology. 1985 ; Vol. 12, No. 3 SUPPL. 4. pp. 90-96.
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