Intraportal islet oxygenation

Thomas M. Suszynski, Efstathios S. Avgoustiniatos, Klearchos K Papas

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Islet transplantation (IT) is a promising therapy for the treatment of diabetes. The large number of islets required to achieve insulin independence limit its cost-effectiveness and the number of patients who can be treated. It is believed that >50% of islets are lost in the immediate post-IT period. Poor oxygenation in the early post-IT period is recognized as a possible reason for islet loss and dysfunction but has not been extensively studied. Several key variables affect oxygenation in this setting, including (1) local oxygen partial pressure (pO2), (2) islet oxygen consumption, (3) islet size (diameter, D), and (4) presence or absence of thrombosis on the islet surface. We discuss implications of oxygen-limiting conditions on intraportal islet viability and function. Of the 4 key variables, the islet size appears to be the most important determinant of the anoxic and nonfunctional islet volume fractions. Similarly, the effect of thrombus formation on the islet surface may be substantial. At the University of Minnesota, average size distribution data from clinical alloislet preparations (n = 10) indicate that >150-μm D islets account for only ∼30% of the total islet number, but >85% of the total islet volume. This suggests that improved oxygen supply to the islets may have a profound impact on islet survivability and function since most of the β-cell volume is within large islets which are most susceptible to oxygen-limiting conditions. The assumption that the liver is a suitable islet transplant site from the standpoint of oxygenation should be reconsidered.

Original languageEnglish (US)
Pages (from-to)575-580
Number of pages6
JournalJournal of diabetes science and technology
Volume8
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Oxygenation
Islets of Langerhans Transplantation
Oxygen
Thrombosis
Hospital Distribution Systems
Oxygen supply
Transplants
Partial Pressure
Insulin
Cost effectiveness
Medical problems
Cell Size
Oxygen Consumption
Liver
Partial pressure
Cost-Benefit Analysis
Volume fraction
Therapeutics

Keywords

  • Anoxia
  • Hypoxia
  • Intraportal transplant
  • Islet transplant
  • Oxygenation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Bioengineering
  • Biomedical Engineering

Cite this

Intraportal islet oxygenation. / Suszynski, Thomas M.; Avgoustiniatos, Efstathios S.; Papas, Klearchos K.

In: Journal of diabetes science and technology, Vol. 8, No. 3, 2014, p. 575-580.

Research output: Contribution to journalArticle

Suszynski, Thomas M. ; Avgoustiniatos, Efstathios S. ; Papas, Klearchos K. / Intraportal islet oxygenation. In: Journal of diabetes science and technology. 2014 ; Vol. 8, No. 3. pp. 575-580.
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