Intrathecal bombesin-induced inhibition of gastrointestinal transit: requirement for an intact pituitary-adrenal axis

Randy J. Koslo, Debra E. Gmerek, Alan Cowan, Frank Porreca

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The role of the pituitary-adrenal axis in the inhibition of gastrointestinal transit caused by intrathecal administration of bombesin was examined. Bombesin (0.3-10 μg) slowed transit by this route in a dose-related manner. Either hypophysectomy or adrenalectomy prevented the inhibition of gastrointestinal transit associated with bombesin (10 μg, i.th.). The inhibitory gut effects of this peptide were not prevented in sham-operated rats. Intrathecal bombesin-induced inhibition of gastrointestinal transit is thus dependent upon an intact pituitary-adrenal axis.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalRegulatory Peptides
Volume14
Issue number3
DOIs
StatePublished - May 1986

Keywords

  • adrenalectomy
  • bombesin
  • gastrointestinal transit
  • hypophysectomy
  • intrathecal

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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