Intrathecal morphine slows gastrointestinal transit in rats

Randy J. Koslo, Jeffry L. Vaught, Alan Cowan, Debra E. Gmerek, Frank Porreca

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Intrathecal (i.th.) (by direct lumbar puncture) and intraperitoneal (i.p.) administration of morphine (30-100 μg/rat) caused a dose-related inhibition of gastrointestinal transit in the rat. Pretreatment with i.th. naloxone (5 μg at -5 min) reversed the effects of i.th., but not i.p., morphine. These results suggest that the spinal cord appears to be a target site for the inhibitory effects of morphine on gastrointestinal transit in the rat.

Original languageEnglish (US)
Pages (from-to)243-246
Number of pages4
JournalEuropean Journal of Pharmacology
Volume119
Issue number3
DOIs
StatePublished - Dec 17 1985
Externally publishedYes

Fingerprint

Gastrointestinal Transit
Morphine
Spinal Puncture
Naloxone
Spinal Cord

Keywords

  • Gastrointestinal transit
  • Intrathecal
  • Morphine
  • Naloxone
  • Rats

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Intrathecal morphine slows gastrointestinal transit in rats. / Koslo, Randy J.; Vaught, Jeffry L.; Cowan, Alan; Gmerek, Debra E.; Porreca, Frank.

In: European Journal of Pharmacology, Vol. 119, No. 3, 17.12.1985, p. 243-246.

Research output: Contribution to journalArticle

Koslo, Randy J. ; Vaught, Jeffry L. ; Cowan, Alan ; Gmerek, Debra E. ; Porreca, Frank. / Intrathecal morphine slows gastrointestinal transit in rats. In: European Journal of Pharmacology. 1985 ; Vol. 119, No. 3. pp. 243-246.
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