Intrathecal morphine slows gastrointestinal transit in rats

Randy J. Koslo, Jeffry L. Vaught, Alan Cowan, Debra E. Gmerek, Frank Porreca

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Intrathecal (i.th.) (by direct lumbar puncture) and intraperitoneal (i.p.) administration of morphine (30-100 μg/rat) caused a dose-related inhibition of gastrointestinal transit in the rat. Pretreatment with i.th. naloxone (5 μg at -5 min) reversed the effects of i.th., but not i.p., morphine. These results suggest that the spinal cord appears to be a target site for the inhibitory effects of morphine on gastrointestinal transit in the rat.

Original languageEnglish (US)
Pages (from-to)243-246
Number of pages4
JournalEuropean Journal of Pharmacology
Volume119
Issue number3
DOIs
StatePublished - Dec 17 1985
Externally publishedYes

Keywords

  • Gastrointestinal transit
  • Intrathecal
  • Morphine
  • Naloxone
  • Rats

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Intrathecal morphine slows gastrointestinal transit in rats'. Together they form a unique fingerprint.

  • Cite this