Intrinsic subthreshold oscillations extend the influence of inhibitory synaptic inputs on cortical pyramidal neurons

Klaus M. Stiefel, Jean-Marc Fellous, Peter J. Thomas, Terrence J. Sejnowski

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Fast inhibitory synaptic inputs, which cause conductance changes that typically last for 10-100 ms, participate in the generation and maintenance of cortical rhythms. We show here that these fast events can have influences that outlast the duration of the synaptic potentials by interacting with subthreshold membrane potential oscillations. Inhibitory postsynaptic potentials (IPSPs) in cortical neurons in vitro shifted the oscillatory phase for several seconds. The phase shift caused by two IPSPs or two current pulses summed non-linearly. Cholinergic neuromodulation increased the power of the oscillations and decreased the magnitude of the phase shifts. These results show that the intrinsic conductances of cortical pyramidal neurons can carry information about inhibitory inputs and can extend the integration window for synaptic input.

Original languageEnglish (US)
Pages (from-to)1019-1026
Number of pages8
JournalEuropean Journal of Neuroscience
Volume31
Issue number6
DOIs
StatePublished - Mar 2010

Fingerprint

Inhibitory Postsynaptic Potentials
Pyramidal Cells
Synaptic Potentials
Membrane Potentials
Cholinergic Agents
Maintenance
Neurons
In Vitro Techniques

Keywords

  • Cortex
  • Hilbert transform
  • Inhibitory postsynaptic potential (IPSP)
  • Oscillations
  • Phase shift

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Intrinsic subthreshold oscillations extend the influence of inhibitory synaptic inputs on cortical pyramidal neurons. / Stiefel, Klaus M.; Fellous, Jean-Marc; Thomas, Peter J.; Sejnowski, Terrence J.

In: European Journal of Neuroscience, Vol. 31, No. 6, 03.2010, p. 1019-1026.

Research output: Contribution to journalArticle

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