Introduction to TRP channels: Structure, function, and regulation

Michael Y. Song, Jason X.J. Yuan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

39 Scopus citations

Abstract

Transient receptor potential or TRP families of ion channels demonstrate great diversity in activation and inhibition, and they are diverse in selectivity of ion conductance. TRP ion channels function as signal integrators through their ion conductance properties, and in some cases kinase activity. They mediate processes such as vision, taste, olfaction, hearing, touch, and thermo- and osmosensation. TRP cation channels function by mediating the flux of Na+ and Ca2+ across the plasma membrane and into the cytoplasm. The influx of cations into the cytoplasm depolarizes cells and is necessary for action potentials in excitable cells such as neurons. In non-excitable cells, membrane depolarization by TRP ) and-channels stimulates voltage- dependent channels (Ca2+, K+, Cl- influences many cellular events, such as transcription, translation, contraction, and migration. TRP channels are important in human physiology, and mutations in TRP genes are associated with at least four diseases. Furthermore, altered expression, function, and/or regulation of TRP channels have been implicated in diseases such as pulmonary hypertension.

Original languageEnglish (US)
Title of host publicationMembrane Receptors, Channels and Transporters in Pulmonary Circulation
EditorsJ.X.J Yuan, J.P.T. Ward
Pages99-108
Number of pages10
DOIs
StatePublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume661
ISSN (Print)0065-2598

Keywords

  • Ankyrin
  • Canonical
  • Melastatin
  • Trpml=Mucolipin
  • Trpn=No mechanoreceptor potential
  • Trpp=Polycystin
  • Vanilliod

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Song, M. Y., & Yuan, J. X. J. (2010). Introduction to TRP channels: Structure, function, and regulation. In J. X. J. Yuan, & J. P. T. Ward (Eds.), Membrane Receptors, Channels and Transporters in Pulmonary Circulation (pp. 99-108). (Advances in Experimental Medicine and Biology; Vol. 661). https://doi.org/10.1007/978-1-60761-500-2_6