Investigating laser-blood vessel interaction with color Doppler optical coherence tomography

Jennifer K Barton, Joseph A. Izatt, Ashley J. Welch

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

A non-invasive method of imaging laser irradiated blood vessels, and of tracking the healing response, has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders such as port wine stains. The CDOCT system uses a superluminescent diode with a center wavelength of 1280 nm. Pulsed dye and KTP lasers operating at 585 and 532 nm, respectively, were used to irradiate rat and hamster dorsal skin flap window models. The window model is a chronic preparation which exposes subdermal blood vessels while maintaining a thickness of normal skin. Irradiation sites were imaged with CDOCT prior to and immediately after laser irradiation, and at intervals up to several days following irradiation. The CDOCT signal was processed to provide both magnitude and color Doppler images. The Doppler signal provides an estimate of the blood flow velocity. The response of blood vessels to radiant exposures above and below the threshold for vessel coagulation was measured. An increase in the blood vessel backscattered signal was observed as blood and vessel walls were coagulated. Changes in blood flow velocity were noted in cases where vessels constricted or flow became occluded.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsV.V. Tuchin, J.A. Izatt, V.V. Tuchin
Pages102-113
Number of pages12
Volume3251
DOIs
StatePublished - 1998
Externally publishedYes
EventCoherence Domain Optical Methods in Biomedical Science and Clinical Applications II - San Jose, CA, United States
Duration: Jan 27 1998Jan 28 1998

Other

OtherCoherence Domain Optical Methods in Biomedical Science and Clinical Applications II
CountryUnited States
CitySan Jose, CA
Period1/27/981/28/98

Fingerprint

Optical tomography
blood vessels
Blood vessels
tomography
Color
color
Lasers
vessels
Blood
lasers
blood flow
Flow velocity
irradiation
interactions
Skin
flow velocity
Irradiation
wines
Wine
hamsters

Keywords

  • Healing response
  • KTP laser
  • Port wine stains
  • Pulsed dye laser

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Barton, J. K., Izatt, J. A., & Welch, A. J. (1998). Investigating laser-blood vessel interaction with color Doppler optical coherence tomography. In V. V. Tuchin, J. A. Izatt, & V. V. Tuchin (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3251, pp. 102-113) https://doi.org/10.1117/12.306044

Investigating laser-blood vessel interaction with color Doppler optical coherence tomography. / Barton, Jennifer K; Izatt, Joseph A.; Welch, Ashley J.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / V.V. Tuchin; J.A. Izatt; V.V. Tuchin. Vol. 3251 1998. p. 102-113.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Barton, JK, Izatt, JA & Welch, AJ 1998, Investigating laser-blood vessel interaction with color Doppler optical coherence tomography. in VV Tuchin, JA Izatt & VV Tuchin (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 3251, pp. 102-113, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II, San Jose, CA, United States, 1/27/98. https://doi.org/10.1117/12.306044
Barton JK, Izatt JA, Welch AJ. Investigating laser-blood vessel interaction with color Doppler optical coherence tomography. In Tuchin VV, Izatt JA, Tuchin VV, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3251. 1998. p. 102-113 https://doi.org/10.1117/12.306044
Barton, Jennifer K ; Izatt, Joseph A. ; Welch, Ashley J. / Investigating laser-blood vessel interaction with color Doppler optical coherence tomography. Proceedings of SPIE - The International Society for Optical Engineering. editor / V.V. Tuchin ; J.A. Izatt ; V.V. Tuchin. Vol. 3251 1998. pp. 102-113
@inproceedings{444e3b2c6a7242bcb1fada1d36d2ec0e,
title = "Investigating laser-blood vessel interaction with color Doppler optical coherence tomography",
abstract = "A non-invasive method of imaging laser irradiated blood vessels, and of tracking the healing response, has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders such as port wine stains. The CDOCT system uses a superluminescent diode with a center wavelength of 1280 nm. Pulsed dye and KTP lasers operating at 585 and 532 nm, respectively, were used to irradiate rat and hamster dorsal skin flap window models. The window model is a chronic preparation which exposes subdermal blood vessels while maintaining a thickness of normal skin. Irradiation sites were imaged with CDOCT prior to and immediately after laser irradiation, and at intervals up to several days following irradiation. The CDOCT signal was processed to provide both magnitude and color Doppler images. The Doppler signal provides an estimate of the blood flow velocity. The response of blood vessels to radiant exposures above and below the threshold for vessel coagulation was measured. An increase in the blood vessel backscattered signal was observed as blood and vessel walls were coagulated. Changes in blood flow velocity were noted in cases where vessels constricted or flow became occluded.",
keywords = "Healing response, KTP laser, Port wine stains, Pulsed dye laser",
author = "Barton, {Jennifer K} and Izatt, {Joseph A.} and Welch, {Ashley J.}",
year = "1998",
doi = "10.1117/12.306044",
language = "English (US)",
volume = "3251",
pages = "102--113",
editor = "V.V. Tuchin and J.A. Izatt and V.V. Tuchin",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - Investigating laser-blood vessel interaction with color Doppler optical coherence tomography

AU - Barton, Jennifer K

AU - Izatt, Joseph A.

AU - Welch, Ashley J.

PY - 1998

Y1 - 1998

N2 - A non-invasive method of imaging laser irradiated blood vessels, and of tracking the healing response, has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders such as port wine stains. The CDOCT system uses a superluminescent diode with a center wavelength of 1280 nm. Pulsed dye and KTP lasers operating at 585 and 532 nm, respectively, were used to irradiate rat and hamster dorsal skin flap window models. The window model is a chronic preparation which exposes subdermal blood vessels while maintaining a thickness of normal skin. Irradiation sites were imaged with CDOCT prior to and immediately after laser irradiation, and at intervals up to several days following irradiation. The CDOCT signal was processed to provide both magnitude and color Doppler images. The Doppler signal provides an estimate of the blood flow velocity. The response of blood vessels to radiant exposures above and below the threshold for vessel coagulation was measured. An increase in the blood vessel backscattered signal was observed as blood and vessel walls were coagulated. Changes in blood flow velocity were noted in cases where vessels constricted or flow became occluded.

AB - A non-invasive method of imaging laser irradiated blood vessels, and of tracking the healing response, has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders such as port wine stains. The CDOCT system uses a superluminescent diode with a center wavelength of 1280 nm. Pulsed dye and KTP lasers operating at 585 and 532 nm, respectively, were used to irradiate rat and hamster dorsal skin flap window models. The window model is a chronic preparation which exposes subdermal blood vessels while maintaining a thickness of normal skin. Irradiation sites were imaged with CDOCT prior to and immediately after laser irradiation, and at intervals up to several days following irradiation. The CDOCT signal was processed to provide both magnitude and color Doppler images. The Doppler signal provides an estimate of the blood flow velocity. The response of blood vessels to radiant exposures above and below the threshold for vessel coagulation was measured. An increase in the blood vessel backscattered signal was observed as blood and vessel walls were coagulated. Changes in blood flow velocity were noted in cases where vessels constricted or flow became occluded.

KW - Healing response

KW - KTP laser

KW - Port wine stains

KW - Pulsed dye laser

UR - http://www.scopus.com/inward/record.url?scp=0032226002&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032226002&partnerID=8YFLogxK

U2 - 10.1117/12.306044

DO - 10.1117/12.306044

M3 - Conference contribution

AN - SCOPUS:0032226002

VL - 3251

SP - 102

EP - 113

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Tuchin, V.V.

A2 - Izatt, J.A.

A2 - Tuchin, V.V.

ER -