7.0T 静息态fMRI分析恒河猴脑默认网络

Translated title of the contribution: Investigation of default mode networks in rhesus macaque brain with 7.0T resting-state fMRI

Xiaowei Fu, Chengzhen Guo, Danzhou Yang, Ying Zhang

Research output: Contribution to journalArticle

Abstract

Objective To investigate default mode networks (DMN) in healthy rhesus monkey brain. Methods Under anesthesia, two healthy rhesus macaques underwent resting-state fMRI at a 7.0T MR scanner. The functional images were firstly normalized to the standard rhesus monkey template 112SM-RL-T1, and the GIFT software was aplied to conduct group-level independent component analysis on all preprocessed functional images. Results The functional connectivity maps of the resting-state networks of rhesus macaques were obtained using this method. DMN bilaterally included posterior cingulate cortex, anterior cingulate cortex, medial parietal cortex, retrosplenial cortex, arcuate sulcus, ventral intraparietal area, temporo-parietal area, superior temporal sulcus dorsal bank and a portion of visual cortex. Conclusion With the help of cutting-edge 7.0T fMRI technology, It was demonstrated that DMN of rhesus macaque brain highly resembled the ones in human, which could support the notion that non-primates are useful models for neuropharmacological and neurocognitive studies.

Translated title of the contributionInvestigation of default mode networks in rhesus macaque brain with 7.0T resting-state fMRI
Original languageChinese
Pages (from-to)801-806
Number of pages6
JournalChinese Journal of Medical Imaging Technology
Volume34
Issue number6
DOIs
StatePublished - Jun 20 2018
Externally publishedYes

Keywords

  • Default mode networks
  • Independent component analysis
  • Magnetic resonance imaging
  • Rhesus macaques

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Physiology (medical)

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