Investigations into the mechanism of immunosuppression caused by acute treatment with O,O,Sttrimethyl phosphorothioate. I. Characterization of the immune cell population affected

Kathy E. Rodgers, Toshiko Imamura, Bruce H. Devens

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Acute administration of O,O,S∼trimethyl phosphorothioate (OOS-TMP), an impurity in technical formulations of malathion, to female C57B1/6 mice was previously shown to suppress the generation of both cytotoxic T lymphocyte to alloantigen and antibody-secreting cells to sheep red blood cells.* * Rodgers KE, Imamura T, Devens BH (1985) Toxicol Appl. Pharmacol Submitted. In this report, macrophages were shown to be the immune cell population most affected by acute OOS-TMP pretreatment by cell separation and reconstitution experiments. Macrophages from OOS-TMP-treated animals had increased levels of nonspecific esterases. In addition, the size distribution of macrophages from treated animals was slightly larger and more heterogeneous than macrophages from control animals. However, macrophages from OOS-TMP-treated animals did not exhibit tumoricidal activity. These data suggest that macrophages from OOS-TMP-treated animals were similar to those located in nonimmune inflammatory sites.

Original languageEnglish (US)
Pages (from-to)171-180
Number of pages10
JournalImmunopharmacology
Volume10
Issue number3
DOIs
StatePublished - Dec 1985
Externally publishedYes

Keywords

  • Immunosuppression
  • Macrophages
  • Mechanism
  • Organophosphate

ASJC Scopus subject areas

  • Pharmacology

Fingerprint

Dive into the research topics of 'Investigations into the mechanism of immunosuppression caused by acute treatment with O,O,Sttrimethyl phosphorothioate. I. Characterization of the immune cell population affected'. Together they form a unique fingerprint.

Cite this