Invited review: Genes involved in the bovine heat stress response

Robert J Collier, J. L. Collier, R. P. Rhoads, L. H. Baumgard

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

The cellular heat stress (HS) response is one component of the acute systemic response to HS. Gene networks within and across cells and tissues respond to environmental heat loads above the thermoneutral zone with both intra- and extracellular signals that coordinate cellular and whole-animal metabolism. Activation of these systems appears to be initiated at skin surface temperatures exceeding 35°C as animals begin to store heat and rapidly increase evaporative heat loss (EVHL) mechanisms. Gene expression changes include 1) activation of heat shock transcription factor 1 (HSF1); 2) increased expression of heat shock proteins (HSP) and decreased expression and synthesis of other proteins; 3) increased glucose and amino acid oxidation and reduced fatty acid metabolism; 4) endocrine system activation of the stress response; and 5) immune system activation via extracellular secretion of HSP. If the stress persists, these gene expression changes lead to an altered physiological state referred to as "acclimation," a process largely controlled by the endocrine system. In the acclimated state, metabolism is adjusted to minimize detrimental effects of increased thermal heat load. The role of secreted HSP in feedback regulation of the immune and endocrine system has not yet been investigated. The variation in EVHL among animals and the central role that HSF1 has in coordinating thermal tolerance suggest that there is opportunity to improve thermal tolerance via gene manipulation. Determining the basis for altered energy metabolism during thermal stress will lead to opportunities for improved animal performance via altered nutritional management.

Original languageEnglish (US)
Pages (from-to)445-454
Number of pages10
JournalJournal of Dairy Science
Volume91
Issue number2
DOIs
StatePublished - Feb 2008

Fingerprint

Heat-Shock Response
Hot Temperature
heat
endocrine system
cattle
Endocrine System
heat shock proteins
Genes
heat stress
Heat-Shock Proteins
genes
heat tolerance
immune system
transcription factors
Immune System
gene expression
animals
skin temperature
metabolism
fatty acid metabolism

Keywords

  • Acclimation
  • Gene expression
  • Heat stress
  • Metabolism

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Food Science

Cite this

Invited review : Genes involved in the bovine heat stress response. / Collier, Robert J; Collier, J. L.; Rhoads, R. P.; Baumgard, L. H.

In: Journal of Dairy Science, Vol. 91, No. 2, 02.2008, p. 445-454.

Research output: Contribution to journalArticle

Collier, Robert J ; Collier, J. L. ; Rhoads, R. P. ; Baumgard, L. H. / Invited review : Genes involved in the bovine heat stress response. In: Journal of Dairy Science. 2008 ; Vol. 91, No. 2. pp. 445-454.
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