Involvement of the ventral tegmental area in a rodent model of post-traumatic stress disorder

Nadia S. Corral-Frias, Ryan P. Lahood, Kimberly E. Edelman-Vogelsang, Edward D French, Jean-Marc Fellous

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Post-traumatic stress disorder (PTSD) is an anxiety disorder of considerable prevalence in individuals who have experienced a traumatic event. Studies of the neural substrate of this disorder have focused on the role of areas such as the hippocampus, the amygdala and the medial prefrontal cortex. We show that the ventral tegmental area (VTA), which directly modulates these areas, is part of this circuitry. Using a rat model of PTSD, we show that a brief but intense foot shock followed by three brief reminders can cause long-term behavioral changes as shown by anxiety-like, nociception, and touch-sensitivity tests. We show that an intraperitoneal injection of a dopamine (DA) antagonist or a bilateral inactivation of the VTA administered immediately before the traumatic event decrease the occurrence or intensity of these behavioral changes. Furthermore, we show that there is a significant decrease of baseline VTA dopaminergic but not GABAergic cell firing rates 2 weeks after trauma. Our data suggest that VTA DA neurons undergo long-term physiological changes after trauma and that this brain area is a crucial part of the circuits involved in PTSD symptomatology.

Original languageEnglish (US)
Pages (from-to)350-363
Number of pages14
JournalNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume38
Issue number2
DOIs
StatePublished - Jan 2013

Fingerprint

Ventral Tegmental Area
Post-Traumatic Stress Disorders
Rodentia
Nociception
Dopamine Antagonists
Dopaminergic Neurons
Touch
Amygdala
Prefrontal Cortex
Anxiety Disorders
Intraperitoneal Injections
Foot
Shock
Hippocampus
Anxiety
Wounds and Injuries

Keywords

  • addiction
  • anxiety
  • dopamine
  • emotion
  • memory
  • nociception

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Involvement of the ventral tegmental area in a rodent model of post-traumatic stress disorder. / Corral-Frias, Nadia S.; Lahood, Ryan P.; Edelman-Vogelsang, Kimberly E.; French, Edward D; Fellous, Jean-Marc.

In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 38, No. 2, 01.2013, p. 350-363.

Research output: Contribution to journalArticle

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