Ion channel gene expression in lung adenocarcinoma: Potential role in prognosis and diagnosis

Jae Hong Ko, Wanjun Gu, Inja Lim, Hyoweon Bang, Eun A. Ko, Tong Zhou

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Ion channels are known to regulate cancer processes at all stages. The roles of ion channels in cancer pathology are extremely diverse. We systematically analyzed the expression patterns of ion channel genes in lung adenocarcinoma. First, we compared the expression of ion channel genes between normal and tumor tissues in patients with lung adenocarcinoma. Thirty-seven ion channel genes were identified as being differentially expressed between the two groups. Next, we investigated the prognostic power of ion channel genes in lung adenocarcinoma. We assigned a risk score to each lung adenocarcinoma patient based on the expression of the differentially expressed ion channel genes. We demonstrated that the risk score effectively predicted overall survival and recurrence-free survival in lung adenocarcinoma. We also found that the risk scores for ever-smokers were higher than those for never-smokers. Multivariate analysis indicated that the risk score was a significant prognostic factor for survival, which is independent of patient age, gender, stage, smoking history, Myc level, and EGFR/KRAS/ALK gene mutation status. Finally, we investigated the difference in ion channel gene expression between the two major subtypes of non-small cell lung cancer: adenocarcinoma and squamous-cell carcinoma. Thirty ion channel genes were identified as being differentially expressed between the two groups. We suggest that ion channel gene expression can be used to improve the subtype classification in non-small cell lung cancer at the molecular level. The findings in this study have been validated in several independent lung cancer cohorts.

Original languageEnglish (US)
Article numbere86569
JournalPLoS One
Volume9
Issue number1
DOIs
StatePublished - Jan 23 2014

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ion channels
adenocarcinoma
Ion Channels
Gene expression
prognosis
lungs
Gene Expression
gene expression
Genes
lung neoplasms
genes
Non-Small Cell Lung Carcinoma
neoplasms
Survival
Cells
Adenocarcinoma of lung
Neoplasms
squamous cell carcinoma
Pathology
multivariate analysis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ion channel gene expression in lung adenocarcinoma : Potential role in prognosis and diagnosis. / Ko, Jae Hong; Gu, Wanjun; Lim, Inja; Bang, Hyoweon; Ko, Eun A.; Zhou, Tong.

In: PLoS One, Vol. 9, No. 1, e86569, 23.01.2014.

Research output: Contribution to journalArticle

Ko, Jae Hong ; Gu, Wanjun ; Lim, Inja ; Bang, Hyoweon ; Ko, Eun A. ; Zhou, Tong. / Ion channel gene expression in lung adenocarcinoma : Potential role in prognosis and diagnosis. In: PLoS One. 2014 ; Vol. 9, No. 1.
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