Iron metabolism in insect disease vectors: Mining the Anopheles gambiae translated protein database

Joy J. Winzerling, Daphne Q.D. Pham

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

All animals require iron for survival. This requirement reflects the role of this mineral as a cofactor of numerous proteins. However, under physiological conditions, Fe2+ oxidizes to Fe3+ encouraging the formation of toxic free radicals. In mammals, the potential for oxidative damage from iron is minimized by binding iron to proteins. Mammalian iron metabolism is complex and numerous proteins are involved in iron absorption, transport, uptake and utilization. We have analyzed the Anopheles gambiae translated protein database for candidates that show identity to proteins involved in mammalian iron metabolism (Holt et al., 2002. The genome sequence of the malaria mosquito Anopheles gambiae. Science 298, 129-149). Our results indicate that proteins involved in iron absorption and intracellular iron utilization are, for the most part, conserved in A. gambiae. In contrast, proteins involved in the pathways of iron export from the gut, transport in hemolymph and uptake at peripheral tissues in mosquitos differ from those for mammals.

Original languageEnglish (US)
Pages (from-to)310-321
Number of pages12
JournalInsect Biochemistry and Molecular Biology
Volume36
Issue number4 SPEC. ISS.
DOIs
StatePublished - Apr 2006

Keywords

  • Anopheles
  • Insect disease vector
  • Iron

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Insect Science

Fingerprint

Dive into the research topics of 'Iron metabolism in insect disease vectors: Mining the Anopheles gambiae translated protein database'. Together they form a unique fingerprint.

Cite this