Iron status in patients receiving erythropoietin for dialysis-associated anemia

D. B. Van Wyck, J. C. Stivelman, Joaquin Ruiz, L. F. Kirlin, M. A. Katz, D. A. Ogden

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Adequate body iron stores are crucial to assuring rapid and complete response to recombinant human erythropoietin (rHuEPO). In the present study, markers of iron storage were examined in 27 patients with normochromic, normocytic anemia undergoing acute rHuEPO (150 to 300 U/kg t.i.w.) treatment for anemia. We calculated projected iron needed for new hemoglobin synthesis from the difference between initial and target hemoglobin concentrations, initial iron reserves available from initial serum ferritin levels, and net projected surplus or deficit from the difference between needs and reserves. Of 22 patients predicted to develop iron deficiency (mean projected deficit 268 ± 70 mg), 20 developed evidence of exhausted iron stores (transferrin %sat < 16 or ferritin < 30 μg/liter) before reaching target hemoglobin; 2 predicted to become deficient (projected deficit < 100 mg) did not; and all 5 predicted to avoid iron deficiency (mean projected surplus 177 ± 20 mg) remained iron replete. During acute rHuEPO therapy net body iron balance remained neutral in patients receiving no iron supplements and increased 5 mg/kg in patients prescribed oral ferrous sulfate. However, in patients given iron dextran i.v. less than 60% of elemental iron administered became measurable as iron stores or usable for hemoglobin synthesis.

Original languageEnglish (US)
Pages (from-to)712-716
Number of pages5
JournalKidney International
Volume35
Issue number2
StatePublished - 1989

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Erythropoietin
Anemia
Dialysis
Iron
Hemoglobins
ferrous sulfate
Ferritins
Transferrin
Dextrans

ASJC Scopus subject areas

  • Nephrology

Cite this

Van Wyck, D. B., Stivelman, J. C., Ruiz, J., Kirlin, L. F., Katz, M. A., & Ogden, D. A. (1989). Iron status in patients receiving erythropoietin for dialysis-associated anemia. Kidney International, 35(2), 712-716.

Iron status in patients receiving erythropoietin for dialysis-associated anemia. / Van Wyck, D. B.; Stivelman, J. C.; Ruiz, Joaquin; Kirlin, L. F.; Katz, M. A.; Ogden, D. A.

In: Kidney International, Vol. 35, No. 2, 1989, p. 712-716.

Research output: Contribution to journalArticle

Van Wyck, DB, Stivelman, JC, Ruiz, J, Kirlin, LF, Katz, MA & Ogden, DA 1989, 'Iron status in patients receiving erythropoietin for dialysis-associated anemia', Kidney International, vol. 35, no. 2, pp. 712-716.
Van Wyck DB, Stivelman JC, Ruiz J, Kirlin LF, Katz MA, Ogden DA. Iron status in patients receiving erythropoietin for dialysis-associated anemia. Kidney International. 1989;35(2):712-716.
Van Wyck, D. B. ; Stivelman, J. C. ; Ruiz, Joaquin ; Kirlin, L. F. ; Katz, M. A. ; Ogden, D. A. / Iron status in patients receiving erythropoietin for dialysis-associated anemia. In: Kidney International. 1989 ; Vol. 35, No. 2. pp. 712-716.
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