Is immune system-related hypertension associated with ovarian hormone deficiency?

Kathryn Sandberg, Hong Ji, Gillian Einstein, April Au, Meredith Hay

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The immune system is known to contribute to the development of high blood pressure in males. However, the role of the immune system in the development of high blood pressure in females and the role of ovarian hormones has only recently begun to be studied. In animal studies, both the sex of the host and the T cell are critical biological determinants of susceptibility and resistance to hypertension induced by angiotensin II. In women, natural menopause is known to result in significant changes in the expression of genes regulating the immune system. Likewise, in animal models, ovariectomy results in hypertension and an upregulation in T-cell tumour necrosis factor-α-related genes. Oestrogen replacement results in decreases in inflammatory genes in the brain regions involved in blood pressure regulation. Together, these studies suggest that the response of the adaptive immune system to ovarian hormone deficiency is a significant contributor to hypertension in women.

Original languageEnglish (US)
Pages (from-to)368-374
Number of pages7
JournalExperimental Physiology
Volume101
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Immune System
Hormones
Hypertension
T-Lymphocytes
Estrogen Replacement Therapy
Ovariectomy
Menopause
Angiotensin II
Genes
Up-Regulation
Animal Models
Tumor Necrosis Factor-alpha
Blood Pressure
Gene Expression
Brain

ASJC Scopus subject areas

  • Physiology

Cite this

Is immune system-related hypertension associated with ovarian hormone deficiency? / Sandberg, Kathryn; Ji, Hong; Einstein, Gillian; Au, April; Hay, Meredith.

In: Experimental Physiology, Vol. 101, No. 3, 01.03.2016, p. 368-374.

Research output: Contribution to journalArticle

Sandberg, Kathryn ; Ji, Hong ; Einstein, Gillian ; Au, April ; Hay, Meredith. / Is immune system-related hypertension associated with ovarian hormone deficiency?. In: Experimental Physiology. 2016 ; Vol. 101, No. 3. pp. 368-374.
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