Ischemic stroke in the elderly

Role of the common factor V mutation causing resistance to activated protein C

Richard D. Press, Xiao Yuan Liu, Nancy Beamer, Bruce M Coull

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Background and Purpose: A common missense mutation in coagulation factor V (Arg 506 Gln) creates phenotypic resistance to the anticoagulant effects of activated protein C and predisposes carriers to venous thrombosis. To assess a correlation between this common hypercoagulable state and ischemic cerebrovascular disease, we have compared the prevalence of this mutation in a group of stroke patients with that in several control patient groups. Methods: The presence of the factor V Arg 506 Gln mutation was determined by a direct polymerase chain reaction-based assay on peripheral blood leukocytes from 161 elderly patients with acute ischemic stroke, 116 elderly patients with stroke risk factors but without acute stroke, 54 healthy elderly control subjects, and 287 younger control individuals (197 blood donors and 90 neonates). Results: The prevalence of the heterozygous Arg 506 Gln factor V mutation was not significantly different in the elderly stroke patients (2.5%) compared with either of the age-matched control groups (2% to 4%). The prevalence of this mutation was significantly higher in each of two younger control groups (~8%) than in the elderly stroke patients (2.5%). Conclusions: The common factor V Arg 506 Gln mutation predisposing to venous thrombosis is not a significant genetic risk factor for ischemic stroke in the elderly.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
JournalStroke
Volume27
Issue number1
StatePublished - Jan 1996
Externally publishedYes

Fingerprint

Activated Protein C Resistance
Factor V
Stroke
Mutation
Venous Thrombosis
Control Groups
Cerebrovascular Disorders
Missense Mutation
Protein C
Blood Donors
Anticoagulants
Leukocytes
Research Design
Newborn Infant
Polymerase Chain Reaction

Keywords

  • blood coagulation
  • cerebrovascular disorders
  • mutation
  • risk factors
  • thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Ischemic stroke in the elderly : Role of the common factor V mutation causing resistance to activated protein C. / Press, Richard D.; Liu, Xiao Yuan; Beamer, Nancy; Coull, Bruce M.

In: Stroke, Vol. 27, No. 1, 01.1996, p. 44-48.

Research output: Contribution to journalArticle

Press, Richard D. ; Liu, Xiao Yuan ; Beamer, Nancy ; Coull, Bruce M. / Ischemic stroke in the elderly : Role of the common factor V mutation causing resistance to activated protein C. In: Stroke. 1996 ; Vol. 27, No. 1. pp. 44-48.
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