Ischemic therapy in thrombocytopenia from hypersplenism

C. L. Witte, T. W. Ovitt, D. B. van Wyck, Marlys H Witte, R. E. O'Mara, J. M. Woolfenden

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Percutaneous transfemoral arterial balloon occlusion or gelatin sponge embolization of the splenic artery or both were carried out in three high-risk patients with hepatic cirrhosis to reduce splenic hyperfunction and improve severe thrombocytopenia. Although this maneuver raised peripheral platelet counts in each patient, in one patient left upper quadrant pain with splinting of the lower chest cage led to hypostatic lower lobe pneumonia, while in another septic splenitis with gas-forming organisms necessitated splenectomy. Transfemoral occlusion of the splenic artery, although an effective, noninvasive approach to control splenic hyperfunction, has at the same time potential dangers that should be viewed with extreme caution in therapeutic application.

Original languageEnglish (US)
Pages (from-to)1115-1121
Number of pages7
JournalArchives of Surgery
Issue number10
Publication statusPublished - 1976


ASJC Scopus subject areas

  • Surgery

Cite this

Witte, C. L., Ovitt, T. W., van Wyck, D. B., Witte, M. H., O'Mara, R. E., & Woolfenden, J. M. (1976). Ischemic therapy in thrombocytopenia from hypersplenism. Archives of Surgery, 111(10), 1115-1121.