Isolated Congenital Lipase—Colipase Deficiency

Fayez K. Ghishan, J. Roberto Moran, Peter R. Durie, Harry L. Greene

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A 5-yr-old child with isolated combined pancreatic lipase and colipase deficiency is described. The patient has a history of passing oily stools since birth. Pancreatic stimulation tests showed that both lipase and colipase activities were <2% of normal control values. Despite the total lack of both enzymes, the patient's fat absorption coefficient was 50%. Fat absorption coefficient increased to 82% with pancreatic enzyme supplementation. This is the first report of congenital combined lipase and colipase deficiency.

Original languageEnglish (US)
Pages (from-to)1580-1582
Number of pages3
JournalGastroenterology
Volume86
Issue number6
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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