Isolated lung perfusion in the management of acute respiratory distress syndrome

Nathan Haywood, Matthew R. Byler, Aimee Zhang, Mark E. Roeser, Irving L. Kron, Victor E. Laubach

Research output: Contribution to journalReview article

Abstract

Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality, and current management has a dramatic impact on healthcare resource utilization. While our understanding of this disease has improved, the majority of treatment strategies remain supportive in nature and are associated with continued poor outcomes. There is a dramatic need for the development and breakthrough of new methods for the treatment of ARDS. Isolated machine lung perfusion is a promising surgical platform that has been associated with the rehabilitation of injured lungs and the induction of molecular and cellular changes in the lung, including upregulation of anti-inflammatory and regenerative pathways. Initially implemented in an ex vivo fashion to evaluate marginal donor lungs prior to transplantation, recent investigations of isolated lung perfusion have shifted in vivo and are focused on the management of ARDS. This review presents current tenants of ARDS management and isolated lung perfusion, with a focus on how ex vivo lung perfusion (EVLP) has paved the way for current investigations utilizing in vivo lung perfusion (IVLP) in the treatment of severe ARDS.

Original languageEnglish (US)
Article number6820
Pages (from-to)1-14
Number of pages14
JournalInternational journal of molecular sciences
Volume21
Issue number18
DOIs
StatePublished - Sep 2 2020

Keywords

  • Acute lung injury
  • Acute respiratory distress syndrome
  • Inflammation
  • Isolated lung perfusion
  • Therapeutics

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Isolated lung perfusion in the management of acute respiratory distress syndrome'. Together they form a unique fingerprint.

  • Cite this