@article{da9814494a0e41f1a9062bb4b274aabe,
title = "It{\textquoteright}s Absolutely Relative: The Effect of Age on the BMI–Mortality Relationship in Postmenopausal Women",
abstract = "Objective: The use of relative and absolute effect estimates has important implications for the interpretation of study findings. Likewise, examining additive and multiplicative interaction can lead to differing conclusions about the joint effects of two exposure variables. The aim of this paper is to examine the relationship between BMI and mortality on the relative and absolute scales and investigate interaction between BMI and age. Methods: Data from 68,132 participants in the Women{\textquoteright}s Health Initiative (WHI) study were used. The risk ratio and risk difference of BMI on mortality were estimated. A product term was also included to examine interaction between BMI and age on the multiplicative scale, and the relative excess risk of interaction was calculated to measure additive interaction. Results: Results demonstrated that the mortality risk ratio decreased as women aged, but the mortality risk difference increased as women aged. Evidence of additive and multiplicative interaction between age and BMI was found. Conclusions: In postmenopausal women, the relative mortality risk associated with high BMI decreased with increasing age, but the absolute risk of high BMI increased with increasing age. This indicates the importance of considering the interaction between age and BMI to understand mortality risk in older women.",
author = "Banack, {Hailey R.} and Bea, {Jennifer W.} and Andrew Stokes and Kroenke, {Candyce H.} and Stefanick, {Marcia L.} and Beresford, {Shirley A.} and Bird, {Chloe E.} and Lorena Garcia and Robert Wallace and Wild, {Robert A.} and Bette Caan and Jean Wactawski-Wende",
note = "Funding Information: We thank Dr. Noel Weiss for his thoughtful comments on an initial version of this analysis. We also acknowledge the Women{\textquoteright}s Health Initiative (WHI): Program Office (National Heart, Lung, and Blood Institute, Bethesda, Maryland), Jacques Rossouw, Shari Ludlam, Joan McGowan, Leslie Ford, and Nancy Geller; Clinical Coordinating Center (Fred Hutchinson Cancer Research Center, Seattle, WA), Garnet Anderson, Ross Prentice, Andrea LaCroix, and Charles Kooperberg; investigators and academic centers, JoAnn E. Manson, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Barbara V. Howard, MedStar Health Research Institute/Howard University, Washington, DC; Marcia L. Stefanick, Stanford Prevention Research Center, Stanford, CA; Rebecca Jackson, The Ohio State University, Columbus, OH; Cynthia A. Thomson, University of Arizona, Tucson/Phoenix, AZ; Jean Wactawski‐Wende, University at Buffalo, Buffalo, NY; Marian Limacher, University of Florida, Gainesville/Jacksonville, FL; Jennifer Robinson, University of Iowa, Iowa City/Davenport, IA; Lewis Kuller, University of Pittsburgh, Pittsburgh, PA; Sally Shumaker, Wake Forest University School of Medicine, Winston‐Salem, NC; Robert Brunner, University of Nevada, Reno, NV; Women{\textquoteright}s Health Initiative Memory Study, Mark Espeland, Wake Forest University School of Medicine, Winston‐Salem, NC. Funding Information: agencies: The Women?s Health Initiative (WHI) program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. HRB is supported by the Banting Postdoctoral Fellowship Program from the Canadian Institutes of Health Research (CIHR).We thank Dr. Noel Weiss for his thoughtful comments on an initial version of this analysis. We also acknowledge the Women?s Health Initiative (WHI): Program Office (National Heart, Lung, and Blood Institute, Bethesda, Maryland), Jacques Rossouw, Shari Ludlam, Joan McGowan, Leslie Ford, and Nancy Geller; Clinical Coordinating Center (Fred Hutchinson Cancer Research Center, Seattle, WA), Garnet Anderson, Ross Prentice, Andrea LaCroix, and Charles Kooperberg; investigators and academic centers, JoAnn E. Manson,?Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Barbara V. Howard,?MedStar Health Research Institute/Howard University, Washington, DC; Marcia L. Stefanick,?Stanford Prevention Research Center, Stanford, CA; Rebecca Jackson,?The Ohio State University, Columbus, OH; Cynthia A. Thomson,?University of Arizona, Tucson/Phoenix, AZ; Jean Wactawski-Wende,?University at Buffalo, Buffalo, NY; Marian Limacher,?University of Florida, Gainesville/Jacksonville, FL; Jennifer Robinson,?University of Iowa, Iowa City/Davenport, IA; Lewis Kuller,?University of Pittsburgh, Pittsburgh, PA; Sally Shumaker,?Wake Forest University School of Medicine, Winston-Salem, NC; Robert Brunner,?University of Nevada, Reno, NV; Women?s Health Initiative Memory Study, Mark Espeland, Wake Forest University School of Medicine, Winston-Salem, NC. Publisher Copyright: {\textcopyright} 2019 The Obesity Society",
year = "2020",
month = jan,
day = "1",
doi = "10.1002/oby.22662",
language = "English (US)",
volume = "28",
pages = "171--177",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "1",
}