IV. Yeast sequencing reports. GUF1, a gene encoding a novel evolutionarily conserved gtpase in budding yeast

Gretchen L. Kiser, Ted A. Weinert

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

While sequencing a region of chromosome IV adjacent to the checkpoint gene MEC3, we identified a gene we call GUF1 (GTPase of Unknown Function), which predicts a 586 amino acid GTPase of the elongation factor‐type class. The predicted Guf1p protein bears striking sequence similarity to both LepA from Escherichia coli (43% identical) and LK1236·1 from Caenorhabditis elegans (42% identical). Analysis of both a guf1δ deletion and a putative constitutive‐activating mutant (GUF1HG) revealed that GUF1 is not essential nor did mutant cells reveal any marked phenotype. The GenBank Accession Number for the GUF1 sequence is U22360.

Original languageEnglish (US)
Pages (from-to)1311-1316
Number of pages6
JournalYeast
Volume11
Issue number13
DOIs
StatePublished - Oct 1995

Keywords

  • GTPase
  • GUF1
  • Saccharomyces cerevisiae
  • chromosome IV

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Genetics

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