Joint match probabilities for Y chromosomal and autosomal markers

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Empirical tests of association between Y chromosome and autosomal markers are presented and a theoretical framework for determining a joint match probability is recommended. Statistical analyses of association were performed in 16 US populations between the autosomal genotypes from loci CSF1PO, FGA, THO1, TPOX, vWA, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S512, D21S11 and Y chromosome haplotypes from loci DYS19, DYS385ab, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS438, and DYS439. The sample populations include individuals of European-, African-, Hispanic-, Native-, and Asian-American ancestry. The results are consistent with independence of Y and autosomal markers, although small amounts of dependence would likely have escaped our tests. Given the data in hand, we suggest it is appropriate to compute joint match probabilities by multiplying the Y haplotype frequency with the appropriately corrected autosomal frequency. In addition to correcting for autosomal frequency differences between groups, a further correction may be required. Since two individuals sharing the same Y haplotype are likely to be more recently related than two randomly chosen individuals, the autosomal frequencies have to be adjusted to account for this, akin to the θ correction used to account for population substructure. The structure imposed on the autosomal frequencies conditioned in a Y match is a function of the number of markers scored and their mutation rate. However, in most settings θ < 0.01. When population structure is already present in the autosomes, the additional effect due to conditioning on the Y is small. For example, if the amount of structure in the population is θ = 0.01 or 0.03 (the NRCII range), then the effect of conditioning on the Y results in only a trivial increase in θ to 0.02-0.04, respectively.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalForensic Science International
Volume174
Issue number2-3
DOIs
StatePublished - Jan 30 2008

Fingerprint

Chromosomes
Joints
Haplotypes
Population
Y Chromosome
Asian Americans
North American Indians
Mutation Rate
Genetic Markers
Hispanic Americans
Hand
Genotype

Keywords

  • Autosomal loci
  • Match probability
  • STR
  • Y chromosome
  • Y-STR

ASJC Scopus subject areas

  • Genetics
  • Analytical Chemistry
  • Pathology and Forensic Medicine
  • Psychiatry and Mental health

Cite this

Joint match probabilities for Y chromosomal and autosomal markers. / Walsh, James "Bruce"; Redd, Alan J.; Hammer, Michael F.

In: Forensic Science International, Vol. 174, No. 2-3, 30.01.2008, p. 234-238.

Research output: Contribution to journalArticle

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