JP-8 jet fuel exposure suppresses the immune response to viral infections

David T. Harris, D. Sakiestewa, D. Titone, X. He, J. Hyde, M. Witten

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. Exposure of mice to JP-8 for 1 /day resulted in immediate secretion of two immunosuppressive agents, namely, interleukin-10 and prostaglandin E2. Thus, it was of interest to determine if jet fuel exposure might alter the immune response to infectious agents. The Hong Kong influenza model was used for these studies. Mice were exposed to 1000 mg/m3 JP-8 (1 /day) for 7 days before influenza viral infection. Animals were infected intra-nasally with virus and followed in terms of overall survival as well as immune responses. All surviving animals were killed 14 days after viral infection. In the present study, JP-8 exposure increased the severity of the viral infection by suppressing the anti-viral immune responses. That is, exposure of mice to JP-8 for 1 /day for 7 days before infection resulted in decreased immune cell viability after exposure and infection, a greater than fourfold decrease in immune proliferative responses to mitogens, as well as an overall loss of CD3+, CD4+, and CD8+ T cells from the lymph nodes, but not the spleens, of infected animals. These changes resulted in decreased survival of the exposed and infected mice, with only 33% of animals surviving as compared with 50% of mice infected but not jet fuel-exposed (and 100% of mice exposed only to JP-8). Thus, short-term, low-concentration JP-8 jet fuel exposures have significant suppressive effects on the immune system which can result in increased severity of viral infections.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalToxicology and Industrial Health
Volume24
Issue number4
DOIs
StatePublished - May 2008

Fingerprint

Virus Diseases
Animals
Jet fuel
Immunosuppressive Agents
Human Influenza
T-cells
Immune system
Viruses
Mitogens
Dinoprostone
Interleukin-10
Cells
Hong Kong
Personnel
Infection
JP8 aviation fuel
Immune System
Cell Survival
Spleen
Air

Keywords

  • Hydrocarbon inhalation
  • Immunotoxicology
  • Influenza
  • Jet fuel
  • JP-8
  • Viruses

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

JP-8 jet fuel exposure suppresses the immune response to viral infections. / Harris, David T.; Sakiestewa, D.; Titone, D.; He, X.; Hyde, J.; Witten, M.

In: Toxicology and Industrial Health, Vol. 24, No. 4, 05.2008, p. 209-216.

Research output: Contribution to journalArticle

Harris, David T. ; Sakiestewa, D. ; Titone, D. ; He, X. ; Hyde, J. ; Witten, M. / JP-8 jet fuel exposure suppresses the immune response to viral infections. In: Toxicology and Industrial Health. 2008 ; Vol. 24, No. 4. pp. 209-216.
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