Ketamine for analgosedation in critically ill patients

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Purpose The purpose of this narrative review is to provide practical and useful guidance for clinicians considering the use of intravenous ketamine for its analgosedative properties in adult, critically ill patients. Methods MEDLINE was searched from inception until January 2016. Articles related to the pharmacological properties of ketamine were retrieved. Information pertaining to pharmacology, pharmacokinetics, dosing regimens, adverse effects, and outcomes was obtained from relevant studies. Results Although the primary mechanism for ketamine's pharmacological effects is N-methyl-D-aspartate blockade, there are several potential mechanisms of action. It has a very large volume of distribution due to its lipophilicity, which can lead to drug accumulation with sustained infusions. Ketamine has several advantages compared with conventional sedatives such as preserving pharyngeal and laryngeal protective reflexes, lowering airway resistance, increasing lung compliance, and being less likely to produce respiratory depression. It causes sympathetic stimulation, which is also unlike other sedatives and analgesics. There are psychotomimetic effects, which are a concern in terms of delirium. Dosing and monitoring recommendations are provided. Conclusions Ketamine has a unique pharmacological profile compared with more traditional agents such as opioids, which makes it an appealing alternative agent for analgosedation in the intensive care unit setting.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalJournal of Critical Care
Volume35
DOIs
StatePublished - Oct 1 2016

Fingerprint

Ketamine
Critical Illness
Pharmacology
Hypnotics and Sedatives
Lung Compliance
Airway Resistance
Delirium
N-Methylaspartate
MEDLINE
Respiratory Insufficiency
Opioid Analgesics
Action Potentials
Intensive Care Units
Reflex
Analgesics
Pharmacokinetics
Pharmaceutical Preparations

Keywords

  • Analgesics
  • Critical care
  • Critical illness
  • Hypnotics and sedatives
  • Ketamine
  • Pain

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Ketamine for analgosedation in critically ill patients. / Erstad, Brian L; Patanwala, Asad E.

In: Journal of Critical Care, Vol. 35, 01.10.2016, p. 145-149.

Research output: Contribution to journalReview article

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