Ki-ras proto-oncogene mutations in sporadic colorectal adenomas: Relationship to histologic and clinical characteristics

Terese Maltzman, Kirsten Knoll, Maria Elena Martinez, Tim Byers, Beth R. Stevens, James R. Marshall, Mary E. Reid, Janine G Einspahr, Nancy Hart, Achyut K Bhattacharyya, Cheryl B. Kramer, Richard Sampliner, David S Alberts, Dennis J. Ahnen

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Abstract

Background & Aims: The goal of this study was to examine the relationship between Ki-ras mutations in colorectal adenomas and characteristics of both the subject (age, gender, and family/personal history of colonic neoplasia) and the adenoma (multiplicity, size, location, and histologic features). Methods: Ki-ras mutations were detected by direct sequencing in 738 adenomatous polyps removed at baseline from 639 participants in a nutritional trial of adenoma recurrence. Results: Ki-ras mutations were detected in 17.2% of the adenomas. Ki-ras mutations were unrelated to gender, family, or personal history of colonic neoplasia, location within the colorectum, or adenoma multiplicity, but were more common in older subjects (P = 0.01 for trend), in larger adenomas (P < 0.0001 for trend), in adenomas with villous histology (odds ratio [OR], 3.2; 95% confidence interval [CI], 2.1-4.9 vs. tubular), and in adenomas with high-grade dysplasia (32.0% vs. 13.6%; OR, 3.0; 95% Cl, 1.9-4.6 vs. low-grade dysplasia). Multivariate analysis showed Ki-ras mutations to be independently associated with subject age (P = 0.01 for trend), tubulovillous/villous histology (OR, 2.3; 95% Cl, 1.5-3.7), and high-grade dysplasia (OR, 1.9; 95% Cl, 1.2-3.1). Adenoma size was not independently related to Ki-ras mutation. Conclusions: Ki-ras mutations are associated with the histologic features of adenoma progression (villous histology and highgrade dysplasia) rather than with adenoma growth.

Original languageEnglish (US)
Pages (from-to)302-309
Number of pages8
JournalGastroenterology
Volume121
Issue number2
Publication statusPublished - 2001

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ASJC Scopus subject areas

  • Gastroenterology

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Maltzman, T., Knoll, K., Martinez, M. E., Byers, T., Stevens, B. R., Marshall, J. R., ... Ahnen, D. J. (2001). Ki-ras proto-oncogene mutations in sporadic colorectal adenomas: Relationship to histologic and clinical characteristics. Gastroenterology, 121(2), 302-309.