Kinetic characterization of a novel cationic 99mTc(I)- tricarbonyl complex, 99mTc-15C5-PNP, for myocardial perfusion imaging

Zhonglin Liu, Liying Chen, Shuang Liu, Christy Barber, Gail D. Stevenson, Lars R. Furenlid, Harrison H. Barrett, James M. Woolfenden

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Intense liver uptake of 99mTc-sestamibi (MIBI) often interferes with visualization of myocardial perfusion in the inferior wall of the left ventricle. To develop improved myocardial perfusion agents, crown ether-containing dithiocarbamates and bisphosphines have been introduced in recent years. This study was designed to investigate the myocardial imaging properties and in vivo kinetics of a cationic 99mTc(I)-tricarbonyl complex, 99mTc-15C5-PNP, in comparison with MIBI. Methods: Dynamic cardiac images were acquired for 60 minutes after intravenous tracer injection using a small-animal SPECT system in healthy control rats and rats with myocardial infarcts. Myocardial and liver time-activity curves were generated for radiopharmaceutical kinetic analysis. Results: Good visualization of the left ventricular wall and perfusion defects could be achieved 20 minutes after 99mTc-15C5-PNP administration. 99mTc-15C5-PNP images in all hearts with infarcts showed perfusion defects, which were comparable to MIBI images. The kinetic curves plotted from 1 to 60 minutes demonstrated that 99mTc-15C5-PNP has a shorter washout half-life (6.4 ± 3.2 vs 124 ± 30.5 minutes, P < .01) in the liver, lower residual liver activity (14.5 ± 10.2% vs 36.5 ± 28.9%, P < .01), and higher heart/liver ratio than MIBI. Conclusions: 99mTc-15C5-PNP has potential for rapid myocardial perfusion imaging with low liver uptake.

Original languageEnglish (US)
Pages (from-to)858-867
Number of pages10
JournalJournal of Nuclear Cardiology
Volume17
Issue number5
DOIs
StatePublished - Oct 1 2010

Keywords

  • SPECT
  • Tc(I)-Tricarbonyl complex
  • heart
  • ischemia
  • rat

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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