Kinetics of digitoxin and the bis- and monodigitoxosides of digitoxigenin in normal subjects

Penelope E. Graves, Paul E Fenster, Ronald T. MacFarland, Frank I. Marcus, Donald Perrier

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6 Citations (Scopus)

Abstract

The kinetics of digitoxin and two of its metabolites, the bis- and monodigitoxosides of digitoxigenin, were determined in six normal subjects. Mean t 1 2s and total body clearances were 134.4, 15.4, and 0.59 hr and 2.66, 27.3, and 1071 ml/min. Mean renal clearance of the monodigitoxoside was more rapid (7.24 ml/min) than those of digitoxin (0.81 ml/min) or the bisdigitoxoside (0.94 ml/min). The volumes of distribution were of the Same order, 0.45 l/kg for digitoxin, 0.57 l/kg for the bisdigitoxoside, and 0.83 l/kg for the monodigitoxoside. The short t 1 2 of monodigitoxoside would make it unsuitable for clinical use, but the bisdigitoxoside of digitoxigenin has a t 1 2 of an intermediate length and may have Significant therapeutic advantages.

Original languageEnglish (US)
Pages (from-to)601-606
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume36
Issue number5
StatePublished - Nov 1984

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Digitoxin
Digitoxigenin
Kidney
digitoxigenin monodigitoxoside
Therapeutics

ASJC Scopus subject areas

  • Pharmacology

Cite this

Kinetics of digitoxin and the bis- and monodigitoxosides of digitoxigenin in normal subjects. / Graves, Penelope E.; Fenster, Paul E; MacFarland, Ronald T.; Marcus, Frank I.; Perrier, Donald.

In: Clinical Pharmacology and Therapeutics, Vol. 36, No. 5, 11.1984, p. 601-606.

Research output: Contribution to journalArticle

Graves, Penelope E. ; Fenster, Paul E ; MacFarland, Ronald T. ; Marcus, Frank I. ; Perrier, Donald. / Kinetics of digitoxin and the bis- and monodigitoxosides of digitoxigenin in normal subjects. In: Clinical Pharmacology and Therapeutics. 1984 ; Vol. 36, No. 5. pp. 601-606.
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