Kinetics of pharmacologic response to cocaine

Michael Mayersohn, D. Perrier

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cocaine plasma concentration-response-time data obtained from the literature were analyzed by pharmacokinetic methods. The plasma concentration-time data yield an elimination half-life of approximately 1 hour and the data suggest that only about 20% of an oral dose of cocaine is absorbed intact into the systemic circulation. Response, as assessed by means of a relative 'high' rating scale, declined linearly with time as predicted by theory. The rate of decline of response was found to be 0.0221 'high'/min. The rate of decline of response is a function of the apparent first-order elimination rate constant (K) of the drug and the slope of the response-log plasma concentration curve (m). A value for m of 4.2 'high' was calculated from the response-time data which agreed well with a value of 3.9 'high' for m determined from the slope of the response-log plasma concentration curve.

Original languageEnglish (US)
Pages (from-to)465-474
Number of pages10
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume22
Issue number3
StatePublished - 1978

Fingerprint

Cocaine
Plasmas
Kinetics
Reaction Time
Pharmacokinetics
Half-Life
Rate constants
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Kinetics of pharmacologic response to cocaine. / Mayersohn, Michael; Perrier, D.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 22, No. 3, 1978, p. 465-474.

Research output: Contribution to journalArticle

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