Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

Alan C. Foster, Annamakia Vezzani, Edward D. French, Robert Schwarcz

Research output: Contribution to journalArticle

312 Scopus citations

Abstract

Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN). In the rat striatum, KYNA blocked the neurotoxic effects of QUIN in preference to those of other excitotoxins. In the hippocampus, KYNA antagonized both the neurodegeneration and seizures caused by the local application of QUIN. These properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalNeuroscience Letters
Volume48
Issue number3
DOIs
StatePublished - Aug 10 1984

Keywords

  • Huntington's disease
  • epilepsy
  • ibotenic acid
  • kainic acid
  • kynurenic acid
  • neurotoxicity
  • quinolinic acid
  • seizures

ASJC Scopus subject areas

  • Neuroscience(all)

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