L-Glutaminase: Suppression of lymphocyte blastogenic responses in vitro

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Abstract

Continuous exposure to 0.1 international unit or more of Escherichia coli L-glutaminase inhibited responses of human lymphocytes to phytohemagglutinin, streptolysin O, and allogeneic leukocytes. Inhibition was completely reversed by removing the enzyme from the culture or adding L-glutamine but not L-asparagine. Cytoxicity did not occur. L-Glutaminase should be immunosuppressive in vivo.

Original languageEnglish (US)
Pages (from-to)736-738
Number of pages3
JournalScience
Volume172
Issue number3984
DOIs
StatePublished - Jan 1 1971

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