L-Glutaminase: Suppression of lymphocyte blastogenic responses in vitro

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Continuous exposure to 0.1 international unit or more of Escherichia coli L-glutaminase inhibited responses of human lymphocytes to phytohemagglutinin, streptolysin O, and allogeneic leukocytes. Inhibition was completely reversed by removing the enzyme from the culture or adding L-glutamine but not L-asparagine. Cytoxicity did not occur. L-Glutaminase should be immunosuppressive in vivo.

Original languageEnglish (US)
Pages (from-to)736-738
Number of pages3
JournalScience
Volume172
Issue number3984
StatePublished - 1971
Externally publishedYes

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Glutaminase
Lymphocytes
Asparagine
Phytohemagglutinins
Immunosuppressive Agents
Glutamine
Leukocytes
Escherichia coli
Enzymes
In Vitro Techniques
streptolysin O

ASJC Scopus subject areas

  • General

Cite this

L-Glutaminase : Suppression of lymphocyte blastogenic responses in vitro. / Hersh, Evan M.

In: Science, Vol. 172, No. 3984, 1971, p. 736-738.

Research output: Contribution to journalArticle

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