L1 retrotransposon and retinoblastoma: Molecular linkages between epigenetics and cancer

D. E. Montoya-Durango, Kenneth Ramos

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Long interspersed nuclear elements (LINEs) are mobile sequences shown to play a fundamental role in eukaryotic genome evolution. Recently, increasing interest has been directed at unveiling molecular mechanisms by which LINE-1 (L1), a ubiquitous member of this family, regulates gene expression and mammalian cell development, differentiation, and cancer. This mini review summarizes recent studies conducted to examine stress-induced L1 reactivation, with special attention given to the role of E2F/Rb transcription factors in epigenetic silencing of L1 and its potential role as a global modifier of chromatin structure and function. The last section focuses on the impact of histone deacetylase inhibitors in the regulation of gene function, chromatin structure, and cancer treatment through alterations in epigenetic signaling.

Original languageEnglish (US)
Pages (from-to)511-521
Number of pages11
JournalCurrent Molecular Medicine
Volume10
Issue number5
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Retroelements
Retinoblastoma
Epigenomics
Chromatin
Genes
E2F Transcription Factors
Histone Deacetylase Inhibitors
Oncology
Gene expression
Cell Differentiation
Neoplasms
Transcription Factors
Cells
Genome
Gene Expression

Keywords

  • Epigenetics
  • Hdac inhibitors
  • Histone methylation
  • Line-1
  • Retinoblastoma

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Medicine(all)

Cite this

L1 retrotransposon and retinoblastoma : Molecular linkages between epigenetics and cancer. / Montoya-Durango, D. E.; Ramos, Kenneth.

In: Current Molecular Medicine, Vol. 10, No. 5, 2010, p. 511-521.

Research output: Contribution to journalArticle

@article{3308357623f34b58870196d991b63574,
title = "L1 retrotransposon and retinoblastoma: Molecular linkages between epigenetics and cancer",
abstract = "Long interspersed nuclear elements (LINEs) are mobile sequences shown to play a fundamental role in eukaryotic genome evolution. Recently, increasing interest has been directed at unveiling molecular mechanisms by which LINE-1 (L1), a ubiquitous member of this family, regulates gene expression and mammalian cell development, differentiation, and cancer. This mini review summarizes recent studies conducted to examine stress-induced L1 reactivation, with special attention given to the role of E2F/Rb transcription factors in epigenetic silencing of L1 and its potential role as a global modifier of chromatin structure and function. The last section focuses on the impact of histone deacetylase inhibitors in the regulation of gene function, chromatin structure, and cancer treatment through alterations in epigenetic signaling.",
keywords = "Epigenetics, Hdac inhibitors, Histone methylation, Line-1, Retinoblastoma",
author = "Montoya-Durango, {D. E.} and Kenneth Ramos",
year = "2010",
doi = "10.2174/156652410791608234",
language = "English (US)",
volume = "10",
pages = "511--521",
journal = "Current Molecular Medicine",
issn = "1566-5240",
publisher = "Bentham Science Publishers B.V.",
number = "5",

}

TY - JOUR

T1 - L1 retrotransposon and retinoblastoma

T2 - Molecular linkages between epigenetics and cancer

AU - Montoya-Durango, D. E.

AU - Ramos, Kenneth

PY - 2010

Y1 - 2010

N2 - Long interspersed nuclear elements (LINEs) are mobile sequences shown to play a fundamental role in eukaryotic genome evolution. Recently, increasing interest has been directed at unveiling molecular mechanisms by which LINE-1 (L1), a ubiquitous member of this family, regulates gene expression and mammalian cell development, differentiation, and cancer. This mini review summarizes recent studies conducted to examine stress-induced L1 reactivation, with special attention given to the role of E2F/Rb transcription factors in epigenetic silencing of L1 and its potential role as a global modifier of chromatin structure and function. The last section focuses on the impact of histone deacetylase inhibitors in the regulation of gene function, chromatin structure, and cancer treatment through alterations in epigenetic signaling.

AB - Long interspersed nuclear elements (LINEs) are mobile sequences shown to play a fundamental role in eukaryotic genome evolution. Recently, increasing interest has been directed at unveiling molecular mechanisms by which LINE-1 (L1), a ubiquitous member of this family, regulates gene expression and mammalian cell development, differentiation, and cancer. This mini review summarizes recent studies conducted to examine stress-induced L1 reactivation, with special attention given to the role of E2F/Rb transcription factors in epigenetic silencing of L1 and its potential role as a global modifier of chromatin structure and function. The last section focuses on the impact of histone deacetylase inhibitors in the regulation of gene function, chromatin structure, and cancer treatment through alterations in epigenetic signaling.

KW - Epigenetics

KW - Hdac inhibitors

KW - Histone methylation

KW - Line-1

KW - Retinoblastoma

UR - http://www.scopus.com/inward/record.url?scp=77954715161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954715161&partnerID=8YFLogxK

U2 - 10.2174/156652410791608234

DO - 10.2174/156652410791608234

M3 - Article

C2 - 20540701

AN - SCOPUS:77954715161

VL - 10

SP - 511

EP - 521

JO - Current Molecular Medicine

JF - Current Molecular Medicine

SN - 1566-5240

IS - 5

ER -