Lack of an adverse effect of Giardia intestinalis infection on the health of Peruvian children

Maria Graciela Hollm-Delgado, Robert H. Gilman, Caryn Bern, Lilia Cabrera, Charles R Sterling, Robert E. Black, William Checkley

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Giardia intestinalis is a common gastrointestinal protozoan worldwide, but its effects on childhood growth in developing countries are not clearly understood. The authors aimed to describe its effects on child growth. They followed 220 Peruvian children daily for diarrhea, weekly for stool samples, and monthly for anthropometry. The authors modeled the effect of nutritional status on the risk of Giardia infection and the risk of diarrhea attributable to Giardia using negative binomial regression. They modeled the effects of Giardia infection on growth using linear regression, with 85% of children becoming infected with Giardia and 87% of these becoming reinfected. In multivariable analysis, the risk of Giardia infection did not vary with weight for age (relative risk = 1.00, 95% confidence interval: 0.89, 1.12) or height for age (relative risk = 0.92, 95% confidence interval: 0.82, 1.04). Giardiasis did not affect growth at 1 or 2 months following the first infection at any age interval. The longitudinal prevalence of Giardia between 6 and 24 months of age was not associated with height gain in that interval (p = 0.981). Giardia was not associated with an increased risk of diarrhea at any age interval. Study results question the importance of Giardia as a childhood pathogen in developing countries where giardiasis is hyperendemic.

Original languageEnglish (US)
Pages (from-to)647-655
Number of pages9
JournalAmerican Journal of Epidemiology
Volume168
Issue number6
DOIs
StatePublished - Sep 2008

Fingerprint

Giardia
Giardia lamblia
Infection
Giardiasis
Diarrhea
Growth
Developing Countries
Confidence Intervals
Anthropometry
Child Health
Nutritional Status
Linear Models
Weights and Measures

Keywords

  • Developing countries
  • Diarrhea
  • Giardia lamblia
  • Growth
  • Natural history
  • Peru

ASJC Scopus subject areas

  • Epidemiology

Cite this

Hollm-Delgado, M. G., Gilman, R. H., Bern, C., Cabrera, L., Sterling, C. R., Black, R. E., & Checkley, W. (2008). Lack of an adverse effect of Giardia intestinalis infection on the health of Peruvian children. American Journal of Epidemiology, 168(6), 647-655. https://doi.org/10.1093/aje/kwn177

Lack of an adverse effect of Giardia intestinalis infection on the health of Peruvian children. / Hollm-Delgado, Maria Graciela; Gilman, Robert H.; Bern, Caryn; Cabrera, Lilia; Sterling, Charles R; Black, Robert E.; Checkley, William.

In: American Journal of Epidemiology, Vol. 168, No. 6, 09.2008, p. 647-655.

Research output: Contribution to journalArticle

Hollm-Delgado, MG, Gilman, RH, Bern, C, Cabrera, L, Sterling, CR, Black, RE & Checkley, W 2008, 'Lack of an adverse effect of Giardia intestinalis infection on the health of Peruvian children', American Journal of Epidemiology, vol. 168, no. 6, pp. 647-655. https://doi.org/10.1093/aje/kwn177
Hollm-Delgado, Maria Graciela ; Gilman, Robert H. ; Bern, Caryn ; Cabrera, Lilia ; Sterling, Charles R ; Black, Robert E. ; Checkley, William. / Lack of an adverse effect of Giardia intestinalis infection on the health of Peruvian children. In: American Journal of Epidemiology. 2008 ; Vol. 168, No. 6. pp. 647-655.
@article{6e3cb056406c451eae4a07b6f211b1a6,
title = "Lack of an adverse effect of Giardia intestinalis infection on the health of Peruvian children",
abstract = "Giardia intestinalis is a common gastrointestinal protozoan worldwide, but its effects on childhood growth in developing countries are not clearly understood. The authors aimed to describe its effects on child growth. They followed 220 Peruvian children daily for diarrhea, weekly for stool samples, and monthly for anthropometry. The authors modeled the effect of nutritional status on the risk of Giardia infection and the risk of diarrhea attributable to Giardia using negative binomial regression. They modeled the effects of Giardia infection on growth using linear regression, with 85{\%} of children becoming infected with Giardia and 87{\%} of these becoming reinfected. In multivariable analysis, the risk of Giardia infection did not vary with weight for age (relative risk = 1.00, 95{\%} confidence interval: 0.89, 1.12) or height for age (relative risk = 0.92, 95{\%} confidence interval: 0.82, 1.04). Giardiasis did not affect growth at 1 or 2 months following the first infection at any age interval. The longitudinal prevalence of Giardia between 6 and 24 months of age was not associated with height gain in that interval (p = 0.981). Giardia was not associated with an increased risk of diarrhea at any age interval. Study results question the importance of Giardia as a childhood pathogen in developing countries where giardiasis is hyperendemic.",
keywords = "Developing countries, Diarrhea, Giardia lamblia, Growth, Natural history, Peru",
author = "Hollm-Delgado, {Maria Graciela} and Gilman, {Robert H.} and Caryn Bern and Lilia Cabrera and Sterling, {Charles R} and Black, {Robert E.} and William Checkley",
year = "2008",
month = "9",
doi = "10.1093/aje/kwn177",
language = "English (US)",
volume = "168",
pages = "647--655",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Lack of an adverse effect of Giardia intestinalis infection on the health of Peruvian children

AU - Hollm-Delgado, Maria Graciela

AU - Gilman, Robert H.

AU - Bern, Caryn

AU - Cabrera, Lilia

AU - Sterling, Charles R

AU - Black, Robert E.

AU - Checkley, William

PY - 2008/9

Y1 - 2008/9

N2 - Giardia intestinalis is a common gastrointestinal protozoan worldwide, but its effects on childhood growth in developing countries are not clearly understood. The authors aimed to describe its effects on child growth. They followed 220 Peruvian children daily for diarrhea, weekly for stool samples, and monthly for anthropometry. The authors modeled the effect of nutritional status on the risk of Giardia infection and the risk of diarrhea attributable to Giardia using negative binomial regression. They modeled the effects of Giardia infection on growth using linear regression, with 85% of children becoming infected with Giardia and 87% of these becoming reinfected. In multivariable analysis, the risk of Giardia infection did not vary with weight for age (relative risk = 1.00, 95% confidence interval: 0.89, 1.12) or height for age (relative risk = 0.92, 95% confidence interval: 0.82, 1.04). Giardiasis did not affect growth at 1 or 2 months following the first infection at any age interval. The longitudinal prevalence of Giardia between 6 and 24 months of age was not associated with height gain in that interval (p = 0.981). Giardia was not associated with an increased risk of diarrhea at any age interval. Study results question the importance of Giardia as a childhood pathogen in developing countries where giardiasis is hyperendemic.

AB - Giardia intestinalis is a common gastrointestinal protozoan worldwide, but its effects on childhood growth in developing countries are not clearly understood. The authors aimed to describe its effects on child growth. They followed 220 Peruvian children daily for diarrhea, weekly for stool samples, and monthly for anthropometry. The authors modeled the effect of nutritional status on the risk of Giardia infection and the risk of diarrhea attributable to Giardia using negative binomial regression. They modeled the effects of Giardia infection on growth using linear regression, with 85% of children becoming infected with Giardia and 87% of these becoming reinfected. In multivariable analysis, the risk of Giardia infection did not vary with weight for age (relative risk = 1.00, 95% confidence interval: 0.89, 1.12) or height for age (relative risk = 0.92, 95% confidence interval: 0.82, 1.04). Giardiasis did not affect growth at 1 or 2 months following the first infection at any age interval. The longitudinal prevalence of Giardia between 6 and 24 months of age was not associated with height gain in that interval (p = 0.981). Giardia was not associated with an increased risk of diarrhea at any age interval. Study results question the importance of Giardia as a childhood pathogen in developing countries where giardiasis is hyperendemic.

KW - Developing countries

KW - Diarrhea

KW - Giardia lamblia

KW - Growth

KW - Natural history

KW - Peru

UR - http://www.scopus.com/inward/record.url?scp=51749117007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51749117007&partnerID=8YFLogxK

U2 - 10.1093/aje/kwn177

DO - 10.1093/aje/kwn177

M3 - Article

C2 - 18669932

AN - SCOPUS:51749117007

VL - 168

SP - 647

EP - 655

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 6

ER -