Lack of effect of diazepam on methadone metabolism in methadone-maintained addicts

Susan M. Pond, Theodore G. Tong, Neal L. Benowitz, Peyton Jacob, Jean Rigod

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Four methadone-maintained subjects were given diazepam (0.3 mg/kg) for 9 days. During the dual drug period, the effects and kinetics of methadone and of its major pyrrolidine metabolite were not altered. These findings indicate that, unlike its effects in rodents, diazepam does not inhibit the metabolism of methadone in man.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume31
Issue number2
DOIs
StatePublished - Feb 1982
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Lack of effect of diazepam on methadone metabolism in methadone-maintained addicts'. Together they form a unique fingerprint.

  • Cite this