Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1

Ivan A. Borbon, Zach Hillman, Ernesto Duran, Pawel R Kiela, Sally A. Frautschy, Robert P. Erickson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In order to determine the efficacy of curcumin in ameliorating symptoms of neurodegeneration in the mouse model of Niemann-Pick C1, a variety of formulations and dosages of curcumin, one comparable to one previously reported as efficacious, were provided orally to Npc1-/-mice. Plasma levels of curcumin, survival, tests of motor performance, and memory (in some cases) were performed. We found variable, but mild, increases in survival (1.5% to 18%). The greatest increased survival occurred with the highest dose (which was unformulated) while the control for the lipidated formulation (containing phosphatidylcholine and stearic acid) had an equivalent impact and other formulations, while not significantly increased, are also not statistically different in effect from the highest dose. We conclude that curcumin is not a highly efficacious treatment for neurodegeneration in Npc1-/- mice. Phosphatidylcholine and stearic acid should be studied further.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume101
Issue number1
DOIs
StatePublished - Mar 2012

Fingerprint

Curcumin
Phosphatidylcholines
Plasmas
Data storage equipment
stearic acid

Keywords

  • Curcumin
  • Memory
  • Motor skills
  • Neurodegeneration
  • Niemann-Pick C

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Pharmacology
  • Toxicology
  • Behavioral Neuroscience
  • Biological Psychiatry

Cite this

Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1. / Borbon, Ivan A.; Hillman, Zach; Duran, Ernesto; Kiela, Pawel R; Frautschy, Sally A.; Erickson, Robert P.

In: Pharmacology, Biochemistry and Behavior, Vol. 101, No. 1, 03.2012, p. 125-131.

Research output: Contribution to journalArticle

Borbon, Ivan A. ; Hillman, Zach ; Duran, Ernesto ; Kiela, Pawel R ; Frautschy, Sally A. ; Erickson, Robert P. / Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1. In: Pharmacology, Biochemistry and Behavior. 2012 ; Vol. 101, No. 1. pp. 125-131.
@article{ecdf9c39beea478f9a05dd1817efff73,
title = "Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1",
abstract = "In order to determine the efficacy of curcumin in ameliorating symptoms of neurodegeneration in the mouse model of Niemann-Pick C1, a variety of formulations and dosages of curcumin, one comparable to one previously reported as efficacious, were provided orally to Npc1-/-mice. Plasma levels of curcumin, survival, tests of motor performance, and memory (in some cases) were performed. We found variable, but mild, increases in survival (1.5{\%} to 18{\%}). The greatest increased survival occurred with the highest dose (which was unformulated) while the control for the lipidated formulation (containing phosphatidylcholine and stearic acid) had an equivalent impact and other formulations, while not significantly increased, are also not statistically different in effect from the highest dose. We conclude that curcumin is not a highly efficacious treatment for neurodegeneration in Npc1-/- mice. Phosphatidylcholine and stearic acid should be studied further.",
keywords = "Curcumin, Memory, Motor skills, Neurodegeneration, Niemann-Pick C",
author = "Borbon, {Ivan A.} and Zach Hillman and Ernesto Duran and Kiela, {Pawel R} and Frautschy, {Sally A.} and Erickson, {Robert P.}",
year = "2012",
month = "3",
doi = "10.1016/j.pbb.2011.12.009",
language = "English (US)",
volume = "101",
pages = "125--131",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1

AU - Borbon, Ivan A.

AU - Hillman, Zach

AU - Duran, Ernesto

AU - Kiela, Pawel R

AU - Frautschy, Sally A.

AU - Erickson, Robert P.

PY - 2012/3

Y1 - 2012/3

N2 - In order to determine the efficacy of curcumin in ameliorating symptoms of neurodegeneration in the mouse model of Niemann-Pick C1, a variety of formulations and dosages of curcumin, one comparable to one previously reported as efficacious, were provided orally to Npc1-/-mice. Plasma levels of curcumin, survival, tests of motor performance, and memory (in some cases) were performed. We found variable, but mild, increases in survival (1.5% to 18%). The greatest increased survival occurred with the highest dose (which was unformulated) while the control for the lipidated formulation (containing phosphatidylcholine and stearic acid) had an equivalent impact and other formulations, while not significantly increased, are also not statistically different in effect from the highest dose. We conclude that curcumin is not a highly efficacious treatment for neurodegeneration in Npc1-/- mice. Phosphatidylcholine and stearic acid should be studied further.

AB - In order to determine the efficacy of curcumin in ameliorating symptoms of neurodegeneration in the mouse model of Niemann-Pick C1, a variety of formulations and dosages of curcumin, one comparable to one previously reported as efficacious, were provided orally to Npc1-/-mice. Plasma levels of curcumin, survival, tests of motor performance, and memory (in some cases) were performed. We found variable, but mild, increases in survival (1.5% to 18%). The greatest increased survival occurred with the highest dose (which was unformulated) while the control for the lipidated formulation (containing phosphatidylcholine and stearic acid) had an equivalent impact and other formulations, while not significantly increased, are also not statistically different in effect from the highest dose. We conclude that curcumin is not a highly efficacious treatment for neurodegeneration in Npc1-/- mice. Phosphatidylcholine and stearic acid should be studied further.

KW - Curcumin

KW - Memory

KW - Motor skills

KW - Neurodegeneration

KW - Niemann-Pick C

UR - http://www.scopus.com/inward/record.url?scp=84855818664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855818664&partnerID=8YFLogxK

U2 - 10.1016/j.pbb.2011.12.009

DO - 10.1016/j.pbb.2011.12.009

M3 - Article

C2 - 22202649

AN - SCOPUS:84855818664

VL - 101

SP - 125

EP - 131

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 1

ER -