Lack of hematologic effects of recent ethanol ingestion by trauma patients

Brian L. Erstad, Cosimo M. Costa, John A. Daller, John B. Fortune

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A retrospective investigation was conducted to determine if acute ethanol (EtOH) ingestion before injury leads to hematologic impairment as noted by coagulation and transfusion parameters. Patients older than 18 years of age were grouped according to the presence or absence of detectable EtOH concentrations in the blood, with further subdivision based on an Injury Severity Score of 8 or less or 9 or more. The following direct and indirect indicators of hematologic function were studied: volume of resuscitation fluids administered (including blood products), prothrombin time, partial thromboplastin time, and hematocrit. Of the 304 patients who were evaluated, 152 had detectable EtOH concentrations and 136 had undetectable EtOH concentrations; 16 patients had not been tested for blood EtOH concentrations and were excluded from the analysis. There were no significant differences between groups with regard to blood or fluid requirements or coagulation parameters. Detectable blood EtOH concentrations in trauma patients are not associated with significant changes in transfusion requirements or coagulation parameters compared to patients without detectable EtOH concentrations.

Original languageEnglish (US)
Pages (from-to)299-302
Number of pages4
JournalAmerican journal of therapeutics
Volume6
Issue number6
DOIs
StatePublished - Nov 1999

Keywords

  • Coagulation
  • Ethanol
  • Hematologic
  • Transfusion
  • Trauma

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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