Abstract
Allopurinol has been reported to decrease the gastrointestinal and bone marrow toxicity of 5-FU when administered in a high dose by continuous infusion. The effect of oxipurinol, the major metabolite of allopurinol, on 5-FU cytotoxicity against three human tumor cell lines was studied using a soft agar clonogenic assay. For both WiDR (colon) and T-47 (breast), 5-FU cytotoxicity was greater in the presence of oxipurinol than in its absence. Oxipurinol did not significantly affect 5-FU cytotoxicity against Hec-1A (endometrial). In none of the three lines was a protective effect of oxipurinol noted.
Original language | English (US) |
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Pages (from-to) | 495-498 |
Number of pages | 4 |
Journal | Cancer Treatment Reports |
Volume | 67 |
Issue number | 5 |
State | Published - 1983 |
ASJC Scopus subject areas
- Oncology
- Cancer Research