Abstract
Allopurinol has been reported to decrease the gastrointestinal and bone marrow toxicity of 5-FU when administered in a high dose by continuous infusion. The effect of oxipurinol, the major metabolite of allopurinol, on 5-FU cytotoxicity against three human tumor cell lines was studied using a soft agar clonogenic assay. For both WiDR (colon) and T-47 (breast), 5-FU cytotoxicity was greater in the presence of oxipurinol than in its absence. Oxipurinol did not significantly affect 5-FU cytotoxicity against Hec-1A (endometrial). In none of the three lines was a protective effect of oxipurinol noted.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 495-498 |
| Number of pages | 4 |
| Journal | Cancer Treatment Reports |
| Volume | 67 |
| Issue number | 5 |
| State | Published - Jan 1 1983 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Garewal, H. S., Ahmann, F. R., & Alberts, D. S. (1983). Lack of inhibition by oxipurinol of 5-FU toxicity against human tumor cell lines. Cancer Treatment Reports, 67(5), 495-498.