Lack of inhibition by oxipurinol of 5-FU toxicity against human tumor cell lines

H. S. Garewal, F. R. Ahmann, D. S. Alberts

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Allopurinol has been reported to decrease the gastrointestinal and bone marrow toxicity of 5-FU when administered in a high dose by continuous infusion. The effect of oxipurinol, the major metabolite of allopurinol, on 5-FU cytotoxicity against three human tumor cell lines was studied using a soft agar clonogenic assay. For both WiDR (colon) and T-47 (breast), 5-FU cytotoxicity was greater in the presence of oxipurinol than in its absence. Oxipurinol did not significantly affect 5-FU cytotoxicity against Hec-1A (endometrial). In none of the three lines was a protective effect of oxipurinol noted.

Original languageEnglish (US)
Pages (from-to)495-498
Number of pages4
JournalCancer Treatment Reports
Volume67
Issue number5
StatePublished - 1983

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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